Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 2.5 mL (840055C-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
10 mg/mL (840055C-25mg)
lipid type
phospholipids
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidylcholine (PC) is a strong bilayer-forming lipid found in mammalian membranes. It consists of a positively charged quaternary amine in the headgroup and a negatively charged phosphate group.
Application
Liver PC is suitable for use:
- in the preparation of two dimensional crystals of microsomal glutathione transferase 1 for electron microscopy
- in the preparation of ′golgi lipid′ mixture for liposome recruitment assay
- in lipid vesicle preparation for ligand transfer assay
Biochem/physiol Actions
Phosphatidylcholine (PC) is an important source of diacylglycerol and other signaling molecules. Liver PC has a saturated to unsaturated fatty acid ratio of 0.91.
Packaging
5 mL Clear Glass Sealed Ampule (840055C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
WGK
WGK 3
Regulatory Information
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The Membranes of Cells (2016)
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation
Witkos TM, et al.
Nature Communications, 10(1), 127-127 (2019)
Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1
Busenlehner LS, et al.
Biochemistry, 43(35), 11145-11152 (2004)
Effect of bilayer phospholipid composition and curvature on ligand transfer by the alpha-tocopherol transfer protein
Zhang WX, et al.
Lipids, 44(7), 631-631 (2009)
The contribution of surface residues to membrane binding and ligand transfer by the alpha-tocopherol transfer protein (alpha-TTP)
Zhang WX, et al.
Journal of molecular biology, 405(4), 972-988 (2011)
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