Product Name
Soy PA, Avanti Research™ - A Croda Brand 840074C
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 2.5 mL (840074C-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 840074C
concentration
10 mg/mL (840074C-25mg)
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidic acid (PA) is a diacyl-glycerophospholipid, with two fatty acids and a phosphate group that are covalently attached to a glycerol molecule through ester linkages. PA is rich in soy lecithin. PA is produced endogenously by the hydrolytic action of the enzyme phospholipase D. It is also produced through phosphorylation of diacyl glycerol (DAG) by diacylglycerol kinases (DGKs).
Application
Soy PA is suitable for use in validation of PA probe.
Biochem/physiol Actions
Phosphatidic acid (PA) is present in biomembranes. It is the precursor for other phospholipids and acts as a signaling molecule. PA is implicated in NAPDH oxidase (NOX) activity.
Packaging
5 mL Clear Glass Sealed Ampule (840074C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
WGK
WGK 3
Regulatory Information
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The mitotic and metabolic effects of phosphatidic acid in the primary muscle cells of turbot (Scophthalmus maximus)
Wang T, et al.
Frontiers in Endocrinology, 9 (2018)
Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation
Schlam D, et al.
Journal of biological and chemical chronicles, 288(32), 23090-23104 (2013)
Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy
Joy JM, et al.
Nutrition, 11(1), 29-29 (2014)
Daniel Schlam et al.
The Journal of biological chemistry, 288(32), 23090-23104 (2013-07-03)
It is commonly assumed that all phagosomes have identical molecular composition. This assumption has remained largely unchallenged due to a paucity of methods to distinguish individual phagosomes. We devised an assay that extends the utility of nitro blue tetrazolium for
Michal Bohdanowicz et al.
Molecular biology of the cell, 24(11), 1700-1712 (2013-04-12)
Macrophages and dendritic cells continuously survey their environment in search of foreign particles and soluble antigens. Such surveillance involves the ongoing extension of actin-rich protrusions and the consequent formation of phagosomes and macropinosomes. The signals inducing this constitutive cytoskeletal remodeling
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