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Merck
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850157P

Avanti

16:0-18:1 PI(4)P

Avanti Research™ - A Croda Brand

Synonym(s):

1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C43H88 N2O16 P2
CAS Number:
2260795-75-1
Molecular Weight:
951.11
UNSPSC Code:
51191904
NACRES:
NA.25

Key Documents

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Product Name

16:0-18:1 PI(4)P, Avanti Research™ - A Croda Brand 850157P, powder

InChI key

YEXVGLIBEQFJQY-PIUDMSOTSA-N

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (with stopper and crimp cap (850157P-1mg))
pkg of 1 × 500 μg (with stopper and crimp cap (850157P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 850157P

lipid type

phospholipids

shipped in

dry ice

storage temp.

−20°C

Application

16:0-18:1 PI(4)P (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)) has been used in liposomes for phosphatidylinositol 4-phosphate 5-kinase (PIP5K) sedimentation assays.

Biochem/physiol Actions

Phosphatidylinositol 4-phosphate (PI(4)P) plays a key role in modulating mitochondrial fission. It participates in protein targeting to the domains of plasma membrane by acting as a spatial cue or signpost.

General description

Phosphatidylinositol 4-phosphate (PI4P) is present abundantly at the plasma membrane.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850157P-1mg)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850157P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

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Certificates of Analysis (COA)

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Deike J Omnus et al.
BMC biology, 18(1), 28-28 (2020-03-15)
Phosphoinositide lipids provide spatial landmarks during polarized cell growth and migration. Yet how phosphoinositide gradients are oriented in response to extracellular cues and environmental conditions is not well understood. Here, we elucidate an unexpected mode of phosphatidylinositol 4-phosphate (PI4P) regulation
Shun Nagashima et al.
Science (New York, N.Y.), 367(6484), 1366-1371 (2020-03-21)
Mitochondrial plasticity is a key regulator of cell fate decisions. Mitochondrial division involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at endoplasmic reticulum (ER) contact sites. The mechanisms driving the final steps of mitochondrial division are still unclear. Here, we
Taki Nishimura et al.
Molecular cell, 75(5), 1043-1057 (2019-08-14)
The plasma membrane (PM) is composed of a complex lipid mixture that forms heterogeneous membrane environments. Yet, how small-scale lipid organization controls physiological events at the PM remains largely unknown. Here, we show that ORP-related Osh lipid exchange proteins are

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