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Merck
CN

850325P

Avanti

10:0 PC

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dicapryl-sn-glycero-3-phosphocholine; PC(10:0/10:0)

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About This Item

Empirical Formula (Hill Notation):
C28H56NO8P
CAS Number:
3436-44-0
Molecular Weight:
565.72
MDL number:
MFCD00063538
UNSPSC Code:
51191904
NACRES:
NA.25

Key Documents

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Product Name

10:0 PC, 1,2-didecanoyl-sn-glycero-3-phosphocholine, powder

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O)=O

InChI

1S/C28H56NO8P/c1-6-8-10-12-14-16-18-20-27(30)34-24-26(25-36-38(32,33)35-23-22-29(3,4)5)37-28(31)21-19-17-15-13-11-9-7-2/h26H,6-25H2,1-5H3

InChI key

MLKLDGSYMHFAOC-UHFFFAOYSA-N

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 200 mg (850325P-200mg)
pkg of 1 × 25 mg (850325P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850325P

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

Application

10:0 PC (DDPC/1,2-didecanoyl-sn-glycero-3-phosphocholine) may be used:
  • as an internal standard to measure lipid metabolites for metabolic profiling using hydrophilic interaction liquid chromatography (HILIC)
  • to prepare lipid bilayer to reconstitute Vpu (membrane protein) and for biophysical studies
  • to prepare phospholipid membrane to study lipid-induced conformation of a 27-residue Cry4Ba-α7 peptide

Biochem/physiol Actions

High or low level of phosphatidylcholine (PC) can affect energy metabolism in several organelles.

General description

10:0 PC (DDPC/1,2-didecanoyl-sn-glycero-3-phosphocholine) is a zwitterionic and shorter-acyl chain phospholipid.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Packaging

20 mL Clear Glass Screw Cap Vial (850325P-200mg)
5 mL Clear Glass Sealed Ampule (850325P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Kasorn Tiewsiri et al.
Archives of biochemistry and biophysics, 482(1-2), 17-24 (2008-12-24)
Helix 7 in the Cry4Ba-pore-forming domain contains conserved Tyr(249) and Phe(264) that are crucially involved in mosquito-larvicidal activity. We have now characterized lipid-induced conformation of a 27-residue Cry4Ba-alpha7 peptide in phospholipid membranes using ATR-FTIR and hydrogen/deuterium (H(+)/D(+)) exchange experiments. ATR-FTIR
Sang Ho Park et al.
Journal of molecular biology, 350(2), 310-318 (2005-06-07)
In order to investigate the compensation mechanism of a trans-membrane helix in response to hydrophobic mismatch, the tilt and rotation angles of the trans-membrane helix of Vpu aligned in lipid bilayers of various thickness were determined using orientation-dependent frequencies obtained
Jelske N van der Veen et al.
Biochimica et biophysica acta. Biomembranes, 1859(9 Pt B), 1558-1572 (2017-04-16)
Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co-workers performed groundbreaking research that established the general outline of many of the pathways of phospholipid biosynthesis. In recent
Chun-Cheih Chao et al.
Cell, 179(7), 1483-1498 (2019-12-10)
Metabolism has been shown to control peripheral immunity, but little is known about its role in central nervous system (CNS) inflammation. Through a combination of proteomic, metabolomic, transcriptomic, and perturbation studies, we found that sphingolipid metabolism in astrocytes triggers the

Articles

Critical Micelle Concentrations (CMCs) - Avanti Research™ Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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