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经验公式（希尔记法）:
C52H90O25
化学文摘社编号:
分子量:
1115.26
MDL number:
UNSPSC Code:
12161902
NACRES:
NA.25
产品名称
Facade™-EM, 3α-hydroxy-7α,12α-di-((O-β-D-maltosyl)-2-hydroxyethoxy)-cholane, powder
assay
>99% (TLC)
form
powder
mol wt
1115.26 g/mol
packaging
pkg of 1 × 1 g (850522P-1g), pkg of 1 × 200 mg (850522P-200mg), pkg of 1 × 25 mg (850522P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850522P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@H]2OCCO[C@@H]4[C@@H](O)[C@H](O)[C@@H](O[C@H]5[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O5)[C@H](CO)O4)([H])C[C@H](OCCO[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](CO)O6)[C@@]
General description
Facade-EM is a two-dimensional amphiphile with hydrophobic and hydrophilic faces that has superior ability to stabilize integral membrane proteins. This new class of detergents represents a departure from traditional one-dimensional polar-head/nonpolar-tail molecules.
Application
Facade™EM (3α-hydroxy-7α,12α-di-((O-β-D-maltosyl)-2-hydroxyethoxy)-cholane) may be used:
- as a facial amphiphile detergent to purify protoxin-II (ProTx2)-voltage-sensor domain II (VSD2)-voltage-gated sodium (NavAb) channel
- as an additive in fluorescence quenching experiments of pentaene-SM 18
- to form isotropic bicelles with p75 for nuclear magnetic resonance (NMR) studies
Biochem/physiol Actions
Facades can be used for the crystallization of membrane proteins since they are considered as optimized membrane mimetics.
Packaging
20 mL Clear Glass Screw Cap Vial (850522P-1g)
20 mL Clear Glass Screw Cap Vial (850522P-200mg)
5 mL Amber Glass Screw Cap Vial (850522P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids