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857392O

Avanti

(R)-FTY720-OMe

Avanti Research™ - A Croda Brand

Synonym(s):

(R)-FTY720-methyl ether; ROME

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About This Item

Empirical Formula (Hill Notation):
C20H35NO2
CAS Number:
1382486-90-9
Molecular Weight:
321.50
MDL number:
MFCD16621009
UNSPSC Code:
12352211
NACRES:
NA.25

Product Name

(R)-FTY720-OMe, (R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol, neat oil

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mg (857392O-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 857392O

lipid type

sphingolipids
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

General description

(R)-FTY720-OMe is the analogue of FTY720.
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.

Biochem/physiol Actions

(R)-FTY720-OMe helps to block DNA synthesis and actin rearrangement induced by sphingosine 1-phosphate (S1P) in MCF-7 breast cancer cells. It can also reduce sphingosine kinase 2 (SK2) expression and prevent DNA synthesis in HEK 293 cells. (R)-FTY720-OMe has anti-breast cancer potential.

Packaging

5 mL Amber Glass Screw Cap Vial (857392O-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

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