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关于此项目
经验公式（希尔记法）:
C20H35NO2
化学文摘社编号:
分子量:
321.50
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
(R)-FTY720-OMe, (R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol, neat oil
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mg (857392O-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857392O
lipid type
sphingolipids
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
General description
(R)-FTY720-OMe is the analogue of FTY720.
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.
Biochem/physiol Actions
(R)-FTY720-OMe helps to block DNA synthesis and actin rearrangement induced by sphingosine 1-phosphate (S1P) in MCF-7 breast cancer cells. It can also reduce sphingosine kinase 2 (SK2) expression and prevent DNA synthesis in HEK 293 cells. (R)-FTY720-OMe has anti-breast cancer potential.
Packaging
5 mL Amber Glass Screw Cap Vial (857392O-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
10 - Combustible liquids
wgk
WGK 3