Product Name
DSPE-PEG(5000) Maleimide, Avanti Research™ - A Croda Brand 880224P, powder
SMILES string
O=C(CCCCCCCCCCCCCCCCC)OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP([O-])(OCCNC([(OCH2CH2)113]NC(CCN1C(C=CC1=O)=O)=O)=O)=O.[NH4+]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (880224P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880224P
shipped in
dry ice
storage temp.
−20°C
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Application
DSPE-PEG(5000) maleimide is suitable for the preparation of cationic liposomes for loading siRNA.. It has also been conjugated with Asn-Gly-Arg to prepare NLC (nanostructured lipid carrier).
Biochem/physiol Actions
Maleimide are useful in biomolecular conjugation. DSPE-PEG(5000) maleimide is used to prepare conjugated polymer nanoparticles.
Packaging
5 mL Amber Glass Screw Cap Vial (880224P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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Conjugated Polymers for Biological and Biomedical Applications, 29-29 (2018)
Catalysis of imido-group hydrolysis in a maleimide conjugate
Kalia J and Raines RT
Bioorganic & Medicinal Chemistry Letters, 17, 6286?6289-6286?6289 (2007)
Yang Yang et al.
Biomaterials, 48, 84-96 (2015-02-24)
Tumor-oriented nanocarrier drug delivery approaches with photosensitivity have drawn considerable attention over the years. However, due to its low penetrability and ability to harm tissues, the use of UV light for triggered nanocarrier release in in vivo applications has been
Yanfang Yang et al.
Journal of pharmaceutical sciences, 104(4), 1328-1339 (2015-01-30)
A novel nanostructured lipid carrier (NLC) modified with photon-sensitive cell penetrating peptides (psCPP) and Asn-Gly-Arg (NGR) was designed to enhance paclitaxel (PTX)-targeted delivery and antitumor effect. The NGR moiety selectively binds to CD13-positive tumors. On other hand, the psCPP moiety
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