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Merck
CN

880228C

Avanti

DSPE-PEG(2000) Azide

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
1938081-40-3
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

DSPE-PEG(2000) Azide, Avanti Research™ - A Croda Brand 880228C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[N-]=[N+]=NCCO.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOOCC.CCOO(CC)OCC.[NH

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (880228C-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880228C

concentration

10 mg/mL (880228C-10mg)

shipped in

dry ice

storage temp.

−20°C

Application

DSPE-PEG(2000) Azide or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] has been used in preparation of azide functionalized liposomes.,It may be used in preparation of drug nanocrystal loaded liposomes and in the production of synthetic platelets (SynthoPlate).

General description

DSPE-PEG(2000) Azide, also referred as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000], is a functionalized polyethylene glycol (PEG) lipid.

Packaging

5 mL Clear Glass Sealed Ampule (880228C-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

Regulatory Information

危险化学品
易制毒化学品（2类）
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Mitchell R Dyer et al.
The journal of trauma and acute care surgery, 84(6), 917-923 (2018-03-15)
Clinical resuscitative treatment of traumatic hemorrhage involves transfusion of RBC, platelets and plasma in controlled ratios. However, use of such blood components, especially platelets, present many challenges including availability, portability, contamination risks, and short shelf-life, which limit the use of
Yunxin Xiao et al.
Colloids and surfaces. B, Biointerfaces, 182, 110362-110362 (2019-07-28)
Liposomal formulations have important therapeutic applications in anti-cancer treatments but current formulations suffer from serious side effects, high dosage requirements and prolonged treatment. In this study, PEGylated azide-functionalized liposomes containing drug nanocrystals were investigated with the aim of increasing the
Elizabeth D Hood et al.
Bioconjugate chemistry, 29(11), 3626-3637 (2018-09-22)
Liposomes are a proven, versatile, and clinically viable technology platform for vascular delivery of drugs and imaging probes. Although targeted liposomes have the potential to advance these applications, complex formulations and the need for optimal affinity ligands and conjugation strategies
Jungwook Paek et al.
ACS nano, 13(7), 7627-7643 (2019-06-14)
The vasculature is an essential component of the circulatory system that plays a vital role in the development, homeostasis, and disease of various organs in the human body. The ability to emulate the architecture and transport function of blood vessels
John C Jewett et al.
Journal of the American Chemical Society, 132(11), 3688-3690 (2010-03-02)
Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole

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