189480-M
Autocamtide-2 Related Inhibitory Peptide
The Autocamtide-2 Related Inhibitory Peptide controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Autocamtide-2 Related Inhibitory Peptide, AIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
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About This Item
Empirical Formula (Hill Notation):
C64H116N22O19
Molecular Weight:
1497.74
UNSPSC Code:
12352202
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
storage temp.
−20°C
General description
Non-phosphorylatable analog of Autocamptide-2 (Cat. No. 189475) that is a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM) and is 50 and 500 times more potent than Ala286-CaM kinase II inhibitor, 281-301 (Cat. No. 208710) and KN-93 (Cat. No. 422708), respectively. Has no effect of PKA, PKC, and CaM kinase IV.
Non-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM). It is about 50 times more potent than [Ala286]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca2+-induced insulin secretion from electropermeabilized islets.
Biochem/physiol Actions
Target IC50: 40 nM against calmodulin-dependent protein kinase II
Other Notes
Bhat, H.S., et al. 2000. Biochem. Pharmacol.60, 1655.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.
H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 189480-500UG | 04055977221770 |