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219498

Cathepsin S Substrate, Fluorogenic

Name: Cathepsin S Substrate, Fluorogenic
Brand: MM

An internally quenched, highly cathepsin S-selective, fluorogenic peptide substrate that is efficiently cleaved by CatS, but not by Cathepsin B & L.

Synonym(s):

Cathepsin S Substrate, Fluorogenic, Mca-GRWPPMG~LPWEK(Dnp)- D-R-NH2, Mca-GRWPPMG~LPWEK(Dnp)-D-R-NH2

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About This Item

Empirical Formula (Hill Notation):

C₉₃H₁₂₃N₂₅O₂₃S

Molecular Weight:

1991.19

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Properties

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

yellow

solubility

DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

Description

General description

An internally quenched, highly cathepsin S-selective, fluorogenic peptide substrate that is efficiently cleaved by CatS (k_cat/K_m = 1.018 µM^-1 S^-1), but not by Cathepsin B & L (k_cat/K_m = 0.004 and 0.032 µM^-1 S^-1, respectively). Studies using CatS-specific inhibitor LHVS reveal that the substrate is not cleaved by other proteolytic enzymes, including CatB, CatH, CatL, and CatX, present in endosomal extracts from human B cell line WT100, dendritic cells, and macrophages (excitation maximum: 340 nm; emission maximum: 405 nm).

Packaging

Packaged under inert gas

Other Notes

Lutzner, N., and Kalbacher, H. 2008. J. Biol. Chem.283, 36185.

Mca-Gly-Arg-Trp-Pro-Pro-Met-Gly~Leu-Pro-Trp-Glu-Lys(Dnp)-D-Arg-NH₂

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c