324833-M
EGFR Inhibitor III
The EGFR Inhibitor III, also referenced under CAS 733009-42-2, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
EGFR Inhibitor III, N-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
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About This Item
Empirical Formula (Hill Notation):
C16H10Cl3FN4O
CAS Number:
Molecular Weight:
399.63
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL (Use fresh, anhydrous DMSO.)
storage temp.
−20°C
General description
A cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.
Biochem/physiol Actions
Primary Target
EGFR
EGFR
Target IC50: 0.7 µM and 1.1 µM suppressesing leiomyoma and myometrical cell proliferation, respectively
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Shushan, A., et al. 2007. Fertil. Steril.87, 127.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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