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Merck
CN

325001

Epothilone B, Synthetic

A structural analog of Epothilone A with similar biological properties.

Synonym(s):

Epothilone B, Synthetic, EpoB

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About This Item

Empirical Formula (Hill Notation):
C27H41NO6S
CAS Number:
152044-54-7
Molecular Weight:
507.68
UNSPSC Code:
12352200
MDL number:
MFCD02101921

Key Documents

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Product Name

Epothilone B, Synthetic, A structural analog of Epothilone A with similar biological properties.

InChI

1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

InChI key

QXRSDHAAWVKZLJ-PVYNADRNSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to off-white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Not available for sale in Germany.

Biochem/physiol Actions

Cell permeable: no
Primary Target
P-glycoprotein-expressing multidrug resistant (MDR) cells
Product does not compete with ATP.
Reversible: no
Target IC50: 2 nM for MDR CCRF-CEM/VBL100 cells

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

General description

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2904.
Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
Nicolaou, K.C., et al. 1997. Nature 387, 268.
Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Certificates of Analysis (COA)

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