主要文件

查看所有文档

344085

Folimycin, Streptomyces sp.

Name: Folimycin, <i>Streptomyces</i> sp.
Brand: MM

A highly sensitive and specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 20 pM).

别名:

Folimycin, Streptomyces sp., Concanamycin A

登录查看组织和合同定价。

选择规格

变更视图

关于此项目

经验公式（希尔记法）:

C₄₆H₇₅NO₁₄

化学文摘社编号:

80890-47-7

分子量:

866.09

UNSPSC Code:

12352200

MDL number:

MFCD00210037

Assay:

≥90% (HPLC)

Form:

lyophilized solid

Storage condition:

OK to freeze, protect from light

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Segment

100

assay

≥90% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

solubility

DMSO: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26-,27-,28-,29+,30+,31-,32+,33-,34-,35+,37-,38+,39+,40-,41-,42-,43-,46-/m1/s1

InChI key

DJZCTUVALDDONK-HQMSUKCRSA-N

说明

General description

A highly sensitive and specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Vacuolar-type H+-ATPase

Product does not compete with ATP.

Reversible: no

Target K_i: 20 pM against vacuolar-type H+-ATPase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

Further dilute with aqueous buffers just prior to use.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kane, M.D., et al. 1999. J. Neurochem.72, 1939.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun.212, 255.
Muroi, M., et al. 1994. Biosci. Biotech. Biochem.58, 425.
Drose, S., et al. 1993. Biochemistry32, 3902.
Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun.193, 999.
Muroi, M., et al. 1993. Cell Struct. Funct.18, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330,H319

pcodes

P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c