444251-M
MMP-2/MMP-9 Inhibitor III
The MMP-2/MMP-9 Inhibitor III controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
MMP-2/MMP-9 Inhibitor III
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About This Item
Empirical Formula (Hill Notation):
C52H71N13O14S2
Molecular Weight:
1166.33
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Level
assay
≥97% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 5 mg/mL
storage temp.
−20°C
General description
A cyclic peptide that acts as a potent inhibitor of MMP-2 (gelatinase A; IC50 = 10 µM) and MMP-9 (gelatinase B; IC50 = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models.
A hydrophobic cyclic peptide that acts as a potent inhibitor of MMP-2 and MMP-9 (IC50 = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models. Also, phage that display this peptide specifically targets angiogenic blood vessels in vivo.
Biochem/physiol Actions
Target IC50: 10 µM against MMP-2 and MMP-9
Other Notes
H-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)
Medina, O.P., et al. 2001. Cancer Res.61, 3978.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.
Legal Information
Sold under license of U.S. Patent 6,624,144.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 444251-1MG | 04055977186512 |