5.06415
SB-269970 Hydrochloride
Synonym(s):
SB-269970 Hydrochloride, 5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
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About This Item
Empirical Formula (Hill Notation):
C18H28N2O3S · xHCl
CAS Number:
Molecular Weight:
352.49 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: soluble
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N2[C@H](CCC2)CCN3CCC(CC3)C)c1cc(ccc1)O.Cl
InChI
1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
InChI key
XQCJOYZLWFNDIO-PKLMIRHRSA-N
General description
A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
Biochem/physiol Actions
Primary Target
5-HT₇
5-HT₇
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Tokarski, K. et al. 2012. Pharmacol. Rep.64, 256.
Thomas. D. R. et al. 2000. Br. J. Pharmacol.130, 409.
Lovell, P. J. et al. 2000. J. Med. Chem.43, 342.
Forbes, I. T. et al. 1998. J. Med. Chem.41, 655.
Thomas. D. R. et al. 2000. Br. J. Pharmacol.130, 409.
Lovell, P. J. et al. 2000. J. Med. Chem.43, 342.
Forbes, I. T. et al. 1998. J. Med. Chem.41, 655.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 5064150001 | 04055977243314 |