5.08438
Lamellipodial Growth Promoter, C8N6 BPA Polyamine
别名:
Lamellipodial Growth Promoter, C8N6 BPA Polyamine, Actin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
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关于此项目
经验公式（希尔记法）:
C20H48N6 · 6HCl
化学文摘社编号:
分子量:
591.40
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352116
Assay:
≥95% (NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥95% (NMR)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: 100 mg/mL, DMSO: 50 mg/mL
storage temp.
2-8°C
General description
A cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Packaging
Packaged under inert gas
Other Notes
Nedeva, I., et al. 2013. Nat. Commun.4, 2165.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable