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Merck
CN

5.30509

StemSelect Compound E

≥95% (HPLC), liquid, γ-secretase inhibitor, Calbiochem®

Synonym(s):

StemSelect Compound E, ( S, S)- 2-(2-(3,5-Difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide, InSolution γ-Secretase Inhibitor XXI, Compound E

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About This Item

Empirical Formula (Hill Notation):
C27H24F2N4O3
CAS Number:
209986-17-4
Molecular Weight:
490.50
MDL number:
MFCD04974531
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

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Product Name

StemSelect Compound E,

SMILES string

Fc1cc(cc(c1)CC(=O)N[C@@H](C)C(=O)NC2N=C(c4c(cccc4)N(C2=O)C)c3ccccc3)F

InChI

1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25?/m0/s1

InChI key

JNGZXGGOCLZBFB-YPHZTSLFSA-N

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

Quality Level

100

Related Categories

General description

Notch signaling suppressor.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
presenilins

Packaging

Packaged under inert gas

Physical form

A 5 mM (250 µg/102 µl), 0.2 µm-filtered solution in DMSO.

Preparation Note

Following initial use, aliquot and freeze (-70°C).

Other Notes

Li, W., et al. 2011. Proc. Natl Acad. Sci. USA108, 8299.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

188.6 °F

flash_point_c

87 °C

Certificates of Analysis (COA)

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