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About This Item

Empirical Formula (Hill Notation):
C22H22N4O2
CAS Number:
385425-03-6
Molecular Weight:
374.44
UNSPSC Code:
12352200
PubChem Substance ID:
6160351
NACRES:
NA.77
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Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 50 mg/mL

storage temp.

−20°C

SMILES string

CC1=CC=C(C=C1)N2C=NC(=C2C(=O)C3=CC=CC=C3)N=CN4CCOCC4

InChI

1S/C22H22N4O2/c1-17-7-9-19(10-8-17)26-16-24-22(23-15-25-11-13-28-14-12-25)20(26)21(27)18-5-3-2-4-6-18/h2-10,15-16H,11-14H2,1H3

InChI key

UCDKLMTYEDPEMY-UHFFFAOYSA-N

General description

A benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes
Reversible: yes

Packaging

Packaged under inert gas

Other Notes

Yang, Z., et al. 2014. Mol. Cell. Biol.34, 1607.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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