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Merck
CN

567051-M

Sinefungin

InSolution, ≥95%, antibiotic

Synonym(s):

InSolution Sinefungin, SF, Adenosyl-ornithine, A9145

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About This Item

Empirical Formula (Hill Notation):
C15H23N7O5
CAS Number:
Molecular Weight:
381.39
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze
protect from light
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Product Name

Sinefungin, InSolution, ≥95%, antibiotic

assay

≥95% (HPLC)

form

liquid

SMILES string

[n]2(c3ncnc(c3nc2)N)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C[C@@H](N)CC[C@H](N)C(=O)O

InChI

1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1

InChI key

LMXOHSDXUQEUSF-YECHIGJVSA-N

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

storage temp.

−20°C

Quality Level

Biochem/physiol Actions

Primary Target
S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase

Disclaimer

Toxicity: Standard Handling (A)

General description

An anti-leishmanial nucleoside antibiotic that acts as an S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase-specific inhibitor.

Other Notes

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Lin, Q., et al. 2001. J. Am. Chem. Soc.123, 11608.
Zingg, J.M., et al. 1996. Nucleic Acids Res.24, 3267.
McCammon, M.T., and Parks, L.W. 1981. J. Bacteriol.145, 106.
Pugh, C.S.G., et al. 1978. J. Biol. Chem.253, 4075.

Physical form

A 10 mM (2 mg/524 µl) solution in H₂O.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

涉药品监管产品
This item has

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