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Merck
CN

572888-M

SU1498

A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase.

Synonym(s):

SU1498, (E)-3-(3,5-Diisopropyl-4-hydroxyphenyl)-2-[(3-phenyl-n-propyl)amino-carbonyl]acrylonitrile, VEGFR Tyrosine Kinase Inhibitor VIII, VEGFR2 Kinase Inhibitor X

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About This Item

Empirical Formula (Hill Notation):
C25H30N2O2
Molecular Weight:
390.52
UNSPSC Code:
12352200
NACRES:
NA.32
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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assay

≥95% (HPLC)

form

solid

potency

700 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 5 mg/mL

storage temp.

−20°C

Quality Level

100

Related Categories

General description

A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase. Also reduces the expression of ets-1, a transcription factor stimulated by VEGF. Has only a weak inhibitory effect on PDGF-receptor (IC50 >50 µM), EGF-receptor (IC50 >100 µM), and HER2 (IC50 >100 µM) kinases. Acts as an angiogenesis inhibitor as shown by its activity in the chorioallantoic membrane (CAM) assay and in an in vivo VEGF-induced permeability assay.

Biochem/physiol Actions

Primary Target
Flk-1 kinase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Arbiser, J.L., et al. 2000. Am. J. Pathol. 156, 1469.
Strawn, L.M., et al. 1996. Cancer Res. 56, 3540.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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