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Merck
CN

647926-M

Trichostatin A, Streptomyces sp.

InSolution, ≥98%, reversible inhibitor of histone deacetylase

Synonym(s):

InSolution Trichostatin A, Streptomyces sp., 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, HDAC Inhibitor IX, TSA

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About This Item

Empirical Formula (Hill Notation):
C17H22N2O3
Molecular Weight:
302.37
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

Trichostatin A, Streptomyces sp., InSolution, ≥98%, reversible inhibitor of histone deacetylase

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Primary Target
histone deactylase
Target IC50: 73 nM inhibiting IL-2 gene expression in Jurkat cells

Disclaimer

Toxicity: Harmful (C)

General description

A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model.

Physical form

A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647925) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Regulatory Information

新产品
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