In skeletal muscles, Pax7 uniquely marks muscle satellite cells and plays some important yet unknown functions at the perinatal stage. Pax3/7BP is a ubiquitously expressed nuclear protein, enriched in Pax7+ muscle precursor cells (MPCs), and serves as an indispensable adaptor for Pax7 to recruit the histone-3-lysine-4 (H3K4) methyltransferase (HMT) complex by bridging Pax7 and Wdr5. Recently, Wu et al. have established Pax3/7BP as an essential adaptor linking Pax3/7 with the H3K4 HMT to regulate the proliferation of muscle progenitor cells.

~105 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Recombinant protein corresponding to mouse PAX3/7BP.

Anti-PAX3/7BP Antibody is an antibody against PAX3/7BP for use in western blotting & IP.

Research Category
Stem Cell Research

Research Sub Category
Muscle Physiology

Developmental Signaling

Unpurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blot in a jurkat cell lysate.
Western Blot Analysis: A 1:1000 dilution of this antibody detected Pax3/7BP in a 10 µg jurkat cell lysate.

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