LRFN5 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while LRFN2 and LRFN5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the LRFN proteins play a role in the developing and/or mature vertebrate nervous system.

~79 kDa observed

At least two isoforms of LRFN5 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family.

KLH-conjugated linear peptide corresponding to human LRFN5.

Detect the LRFN5 protein using this Anti-LRFN5 validated for use in WB & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected LRFN5 in mouse brain tissue.

Research Category
Neuroscience

Research Sub Category
Synapse & Synaptic Biology

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS and 0.02% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
EL4 cell lysate

Evaluated by Western Blot in EL4 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LRFN5 in 15 µg of EL4 cell lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.