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HANG2MAG-12K

MILLIPLEX® Human Angiogenesis Panel

Configurable Human Angiogenesis 19-Plex Panel 2

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

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Product Name

MILLIPLEX® Human Angiogenesis Panel, Configurable Human Angiogenesis 19-Plex Panel 2

species reactivity

human

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

accuracy: 88-97%
standard curve range: 137-100,000 pg/mL
(Thrombospondin-2)
standard curve range: 137-100,000 pg/mL
(sVEGFR2)
standard curve range: 137-100,000 pg/mL
(suPAR)
standard curve range: 14-10,000 pg/mL
(sAXL)
standard curve range: 14-10,000 pg/mL
(sHER3)
standard curve range: 14-10,000 pg/mL
(sVEGFR1)
standard curve range: 27-20,000 pg/mL
(sIL-6Rα)
standard curve range: 27-20,000 pg/mL
(sPECAM-1)
standard curve range: 27-20,000 pg/mL
(sTIE-2)
standard curve range: 274-200,000 pg/mL
(Angiostatin)
standard curve range: 274-200,000 pg/mL
(sE-Selectin)
standard curve range: 274-200,000 pg/mL
(sNeuropilin-1)
standard curve range: 41-30,000 pg/mL
(Osteopontin (OPN))
standard curve range: 41-30,000 pg/mL
(sEGFR)
standard curve range: 41-30,000 pg/mL
(sHER2)
standard curve range: 41-30,000 pg/mL
(sc-Kit/sSCFR)
standard curve range: 412-300,000 pg/mL
(sVEGFR3)
standard curve range: 69-50,000 pg/mL
(sHGFR)
standard curve range: 7-5,000 pg/mL
(PDGF-AB/BB)

technique(s)

multiplexing: suitable

input

serum plasma (Cell culture, cell culture supernatants)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

General description

Angiogenesis, the development of new vascular networks, is a key process in normal growth and development as well as in wound healing, with homeostasis maintained by a delicate balance of angiogenic factors and inhibitors. Consequently, insufficient, or excessive blood vessel growth underlies many diseases, including cardiovascular disease, diabetic ulcers, macular degeneration, and cancer. Angiogenesis plays a significant role in tumor growth and metastasis.

MILLIPLEX® Human Angiogenesis Magnetic Bead Panel 2 is a 19-plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum, plasma, cell culture samples, and tissue homogenates/lysates: Angiostatin, soluble E-Selectin, (sE-Selectin), Osteopontin (OPN), Platelet Derived Growth Factor-AB/BB (PDGF-AB/BB), soluble Platelet Endothelial Cell Adhesion Molecule-1 (sPECAM-1), Thrombospondin-2 (TSP-2), soluble AXL (sAXL), soluble c-Kit/Stem Cell Growth Factor Receptor (sc-Kit/SCFR), soluble Epidermal Growth Factor Receptor (sEGFR)†, soluble Human Epidermal Growth Factor Receptor 2 (sHer2), soluble Human Epidermal Growth Factor Receptor 3 (sHer3), soluble Hepatocyte Growth Factor Receptor/c-Met (sHGFR/c-Met), soluble IL-6Rα, soluble Neuropilin-1 (sNRP-1), soluble Tie-2 (sTie-2), soluble Urokinase-type Plasminogen Activator Receptor (suPAR), soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR1), soluble Vascular Endothelial Growth Factor Receptor 2 (sVEGFR2), and soluble Vascular Endothelial Growth Factor Receptor 3 (sVEGFR3). This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

†Antibody against active site results in preferential binding to unbound EGFR.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Circulating Cancer
Angiogenesis, the development of new vascular networks, is a key process in normal growth and development as well as in wound healing, with homeostasis maintained by a delicate balance of angiogenic factors and inhibitors. Consequently, insufficient, or excessive blood vessel growth underlies many diseases, including cardiovascular disease, diabetic ulcers, macular degeneration, and cancer. Angiogenesis plays a significant role in tumor growth and metastasis.

Other Notes

Sensitivity: See kit protocol for individual analytes sensitivities.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 19 analytes in human serum, plasma, and cell culture supernatants.Analytes included: Angiostatin, soluble E-Selectin, (sE-Selectin), Osteopontin (OPN), Platelet Derived Growth Factor-AB/BB (PDGF-AB/BB), soluble Platelet Endothelial Cell Adhesion Molecule-1 (sPECAM-1), Thrombospondin-2 (TSP-2), soluble AXL (sAXL), soluble c-Kit/Stem Cell Growth Factor Receptor (sc-Kit/SCFR), soluble Epidermal Growth Factor Receptor (sEGFR)†, soluble Human Epidermal Growth Factor Receptor 2 (sHer2), soluble Human Epidermal Growth Factor Receptor 3 (sHer3), soluble Hepatocyte Growth Factor Receptor/c-Met (sHGFR/c-Met), soluble IL-6Rα, soluble Neuropilin-1 (sNRP-1), soluble Tie-2 (sTie-2), soluble Urokinase-type Plasminogen Activator Receptor (suPAR), soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR1), soluble Vascular Endothelial Growth Factor Receptor 2 (sVEGFR2), and soluble Vascular Endothelial Growth Factor Receptor 3 (sVEGFR3)†Antibody against active site results in preferential binding to unbound EGFR.Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

  • Comprehensive Insights into Angiogenesis: By measuring multiple angiogenic factors simultaneously, researchers can gain a deeper understanding of the balance between pro-angiogenic and anti-angiogenic signals, crucial for studying diseases like cancer, cardiovascular conditions, and diabetic ulcers.
  • Flexible Research Applications: Ideal for studying cancer biology, wound healing, and other conditions influenced by angiogenesis, this panel supports a wide range of investigative goals in the field of vascular biology.
  • Configurable Multiplexing Options: Researchers can design their multiplex kit by selecting from the available analytes within the panel, tailoring the assay to meet specific research needs and objectives.
  • 19-Plex Capability: This advanced kit allows for the simultaneous quantification of 19 critical analytes related to angiogenesis, including Angiostatin, soluble E-Selectin, Osteopontin, PDGF-AB/BB, and various soluble growth factor receptors, providing a comprehensive overview of angiogenic activity.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Regulatory Information

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Nicos Mitsides et al.
Nephron, 143(4), 234-242 (2019-09-13)
Progressive chronic kidney disease (CKD) inevitably leads to salt and water retention and disturbances in the macro-and microcirculation. We hypothesize that salt and water dysregulation in advanced CKD may be linked to inflammation and microvascular injury pathways. We studied 23
Sayuri Padayachee et al.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 37(1), 29-34 (2022-08-11)
A dysregulation of angiogenic mediators has been implicated in HIV infection. Inconsistent data exists on highly active antiretroviral therapy (HAART) usage in pregnancy and its association with PE development. In view of the high prevalence of HIV infection and PE
Luka Roškar et al.
Journal of clinical medicine, 10(4) (2021-03-07)
Preoperative determination of the extent of endometrial cancer (EC) would avoid the complications associated with radical surgery. Screening of patients' plasma biomarkers might enable a more precise diagnosis of EC and a tailored treatment approach. This prospective case-control monocentric pilot
Juan Pablo Hinestrosa et al.
Communications medicine, 2, 29-29 (2022-05-24)
Detecting cancer at early stages significantly increases patient survival rates. Because lethal solid tumors often produce few symptoms before progressing to advanced, metastatic disease, diagnosis frequently occurs when surgical resection is no longer curative. One promising approach to detect early-stage

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