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Merck
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HNPMAG-35K

MILLIPLEX® Human Neuropeptide Panel

Configurable Human Neuropeptide 5-Plex Panel

Synonym(s):

Human Neuroscience Protein Multiplex Assay, Luminex® Human Neuroscience Panel, Millipore Human Neuroscience Immunoassay

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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Product Name

MILLIPLEX® Human Neuropeptide Panel,

species reactivity

human

Quality Level

200

description

Configurable Human Neuropeptide 5-Plex Panel

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 98-118%
(Spike Recovery), sensitivity: 11-479 pg/mL
(MinDC+2SD), standard curve range: 27-20,000 pg/mL
(α-MSH), standard curve range: 41-30,000 pg/mL
(Neurotensin), standard curve range: 55-40,000 pg/mL
(Oxytocin), standard curve range: 69-50,000 pg/mL
(β-Endorphine), standard curve range: 7-5,000 pg/mL
(Substance P)

technique(s)

multiplexing: suitable

input

serum
cell culture supernatant

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

General description

The central nervous system comprises billions of neurons and glial cells that communicate through various chemical signals, including neurotransmitters and neuropeptides. Neuropeptides, secreted from both the central and peripheral nervous systems, play crucial roles in regulating metabolism, reproduction, and immunity, and are linked to specific behaviors like bonding and anxiety. Understanding neurobiology and accurately measuring neuropeptides is essential for addressing neurodegenerative diseases such as Alzheimer′s and Parkinson′s.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 5 analytes in human serum, plasma, cerebospinal fluid (CSF), and cell culture supernatants and lysates.

Analytes included: α-Melanocyte Stimulating Hormone (α-MSH), -Endorphin, Neurotensin, Oxytocin, Substance P.

Note: Serum and plasma samples require extraction using acetonitrile precipitation or an extraction plate. See kit protocol for details.Note: This is a competitive assay.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Comprehensive Neuropeptide Coverage: Quantify key neuropeptides such as α-MSH, β-Endorphin, and Oxytocin simultaneously, enhancing your research into neurobiology and disease mechanisms.
  • Sensitivity and Precision: Achieve reliable detection with precision and accuracy, ensuring confidence in your results across various sample types.
  • Customizable Panels: Tailor your kit to include any combination of analytes, allowing for a focused approach that meets your specific research needs.
  • Streamlined Workflow: The all-in-one kit format includes all necessary reagents, simplifying the setup and execution of your assays while saving valuable research time
  • Robust Technical Support: Benefit from dedicated support teams, including expert sales specialists and field application scientists.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Regulatory Information

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Marco Barbariga et al.
Investigative ophthalmology & visual science, 59(3), 1305-1312 (2018-04-07)
The purpose of this study was to investigate the role of substance P (SP) in patients affected with corneal neovascularization (CNV) and in three different Tac1-knockout (KO) murine models of CNV. SP levels in tears were measured with a multiplex
Emmanuel Bäckryd et al.
Pain medicine (Malden, Mass.), 15(1), 111-119 (2013-10-15)
Pain medicine still lacks mechanism-specific biomarkers to guide diagnosis and treatment, and defective top-down modulation is an important factor in the pathophysiology of chronic pain conditions. Using modern analytical tools and advanced multivariate statistical analysis, the aim of this study
Olga V Roschina et al.
Journal of clinical medicine, 10(23) (2021-12-11)
The neuropeptides β-endorphin and oxytocin are released into the bloodstream as hormones from the pituitary gland but also have an important function as neuroregulators in the forebrain. The blood levels of both polypeptides have been shown to reflect depressive symptoms.
Ann M Manzardo et al.
American journal of medical genetics. Part A, 170(9), 2328-2333 (2016-08-16)
Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental disorder associated with maladaptive social behavior, hyperphagia and morbid obesity. Orexin A is a hypothalamic neuropeptide important as a homeostatic regulator of feeding behavior and in energy metabolism through actions in the
Immediate effects of spinal manipulation on nitric oxide, substance P and pain perception.
Molina-Ortega, F; Lomas-Vega, R; Hita-Contreras, F; Plaza Manzano, G; Achalandabaso et al.
Manual therapy null
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