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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
tau-C3, monoclonal
Species reactivity:
human
Application:
ELISA, IHC, WB
Citations:
14
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
tau-C3, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... MAPT(4137)
General description
43 kDa (aa 1 to 421) or smaller fragments with Asp421 as the c-terminus
Immunogen
Epitope: Caspase Cleaved (truncated at Asp421)
Peptide corresponding to the C-terminus of tau truncated as aspartic acid 421.
Application
Anti-Tau Antibody, Caspase Cleaved (truncated at Asp421) is an antibody against Tau for use in ELISA, WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blot
Immunohistochemistry
ELISA
Optimal working dilutions must be determined by end user.
Immunohistochemistry
ELISA
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Reacts with Tau, caspase cleaved (truncated at Asp421). The antibody shows no reactivity with full length tau nor other tau C-terminal truncations. The antibody stains amyloid beta treated neurons and brain tissue in Alzheimer′s disease, more specifically it stains a subset of neurofibrillary tangles, tau-containing neuritic plaques and neuropil threads.
Physical form
Format: Purified
Purified immunoglobulin. Liquid in PBS. Contains no preservative.
Preparation Note
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Related Content
Alzheimer’s Disease: Amyloid Cascade and Beyond Product Focus
Debra K Kumasaka et al.
International journal of physiology, pathophysiology and pharmacology, 1(1), 48-56 (2009-01-12)
A recent study demonstrated the lack of beta-amyloid (Abeta) plaque formation and accumulation of the amyloid precursor protein (APP) in a triple transgenic mouse model of Alzheimer's disease (3xTg-AD) following overexpression of the anti-apoptotic protein, Bcl-2 (Rohn et al., J.
Patrice Delobel et al.
The American journal of pathology, 172(1), 123-131 (2007-12-15)
Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the assembly of tau into filaments in Alzheimer's disease and other tauopathies. Here we have investigated the time
Tau pathogenesis is promoted by A?1-42 but not A?1-40.
Hu, X; Li, X; Zhao, M; Gottesdiener, A; Luo, W; Paul, S
Mol. Neurodegener. null
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MAB5430 | 04053252316340 |