MABT1491
Anti-ZNF175 (OTK18) Antibody, clone 211−3.1−1
clone 211−3.1−1, from mouse
Synonym(s):
Zinc finger protein OTK18
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
211−3.1−1, monoclonal
species reactivity
human
packaging
antibody small pack of 25 μg
technique(s)
ELISA: suitable
immunocytochemistry: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
target post-translational modification
unmodified
Gene Information
human ... ZNF175(7728)
General description
81.61 kDa calculated.
Zinc finger protein 175 (UniProt: Q9Y473; also known as Zinc finger protein OTK18) is encoded by the ZNF175 gene (Gene ID: 7728) in human. ZNF175 is zinc finger protein that contains 13 C2H2 type zinc fingers and is shown to be ubiquitous in its expression. ZNF175 displays antiviral activity and it is produced during HIV-1 infection of mononuclear phagocytes in human and interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity. It down-regulates the expression of several chemokine receptors and plays a role in the interaction of viral and host cell factors leading to HIV-1 associated dementia and HIV-1 encephalitis. ZNF175 contains a Krüppel associated box (KBAB; aa 26-89) domain that is responsible for its repressive activity. Plasma levels of ZNF175 are reported to correlate with CD8 count and HIV status. (Ref.: Buescher, J., et al. (2008). J Neuroimmune Pharmacol. 3(4); 230-235).
Immunogen
Epitope: N-terminus
His-tagged recombinant fragment corresponding to the first 178 amino acids from the N-terminal region of human Zinc finger protein 175.
Application
Anti-OTK18(ZNF175) clone 211 3.1 1, Cat. No. MABT1491, is a mouse monoclonal antibody that detects Zinc finger protein 175 (OTK18) and has been tested for use in ELISA and Immunocytochemistry.
ELISA Analysis: A representative lot detected OTK18(ZNF175) in ELISA applications (Buescher, J.L., et. al. (2008). J Neuroimmune Pharmacol. 3(4):230-5).
Research Category
Inflammation & Immunology
Inflammation & Immunology
Biochem/physiol Actions
Clone 211 3.1 1 specifically detects human Zinc finger protein 175. It targets an epitope with in the first 178 amino acids from the N-terminal region.
Physical form
Format: Purified
Protein G purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Immunocytochemistry in HeLa cells.
Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected OTK18(ZNF175) in HeLa cells.
Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected OTK18(ZNF175) in HeLa cells.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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