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Merck
CN

D8286

Diflorasone diacetate

analytical standard

Synonym(s):

6α,9-Difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-diacetate

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About This Item

Empirical Formula (Hill Notation):
C26H32F2O7
CAS Number:
Molecular Weight:
494.52
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
251-575-1
MDL number:
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grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

SMILES string

[H][C@@]12C[C@H](C)[C@](OC(C)=O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1

InChI key

BOBLHFUVNSFZPJ-JOYXJVLSSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.


pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

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E A Johansson et al.
Current medical research and opinion, 9(4), 259-264 (1984-01-01)
The efficacy of once a day applications of 0.05% diflorasone diacetate ointment and twice a day applications of 0.1% betamethasone valerate ointment was compared in 70 patients with eczematous dermatitis. Altogether 32 patients completed the 3-week study. Fourteen patients in
W D Schneider
Zeitschrift fur Hautkrankheiten, 59(19), 1312-1312 (1984-10-01)
In a three weeks study, efficacy and local tolerance of 0.05% diflorasone diacetate (Florone) cream and ointment were tested in 60 patients suffering from eczematous dermatosis or dermatitis. The results have been judged by 8 signs of improvement and are
S A Spencer et al.
Cutis, 36(2), 169-172 (1985-08-01)
Nineteen patients with psoriasis were treated with a modified Goeckerman regimen tailored to enhance patient compliance. Treatment consisted of daily coal tar emulsion baths at bedtime, followed by the application of 0.05 percent diflorasone diacetate ointment. Patients received increasing suberythemal