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PHR1134

Supelco

Thymol

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
2-Isopropyl-5-methylphenol, 5-Methyl-2-(1-methylethyl)phenol, 5-Methyl-2-isopropylphenol, IPMP
Linear Formula:
2-[(CH3)2CH]C6H3-5-(CH3)OH
CAS Number:
89-83-8
Molecular Weight:
150.22
Beilstein:
1907135
EC Number:
201-944-8
MDL number:
MFCD00002309
PubChem Substance ID:
329823154

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1449008

vapor pressure

1 mmHg ( 64 °C)

API family

thymol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

232 °C (lit.)

mp

48-51 °C (lit.)

density

0.965 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)c1ccc(C)cc1O

InChI

1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3

InChI key

MGSRCZKZVOBKFT-UHFFFAOYSA-N

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Thymol is a monoterpene phenol with antioxidant, anti-inflammatory, local anaesthetic, antinociceptive, cicatrizing, antibacterial and antifungal properties.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thymol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0147 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Statements

H302 - H314 - H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

240.8 °F - closed cup

Flash Point(C)

116 °C - closed cup

Certificates of Analysis (COA)

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705578-5MG-PW

PL860-CGA/SHF-1EA

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Antibacterial and antifungal activities of thymol: A brief review of the literature
Marchese A, et al.
Food Chemistry, 210, 402-414 (2016)
Spectrophotometric determination of thymol in pharmaceuticals with Gibb's reagent
Al-Neaimy, Usra IS
Journal of Educational Psychology, 22(39) (2009)
Spectrophotometric Determination of Thymol in Pharmaceuticla Formulations Via Oxidative Coupling Reaction
Mohammad, I Kh
Reactive functional Polymers, 17(3) (2005)
Claudia Kohlert et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 767(1), 11-18 (2002-02-28)
A reliable and sensitive method was developed for determination of thymol in human plasma by automated headspace solid-phase microextraction (SPME). After enzymatic cleavage of thymol sulfate thymol was extracted by a 65 microm polydimethylsiloxane-divinylbenzene crimped fiber (Supelco) after addition of
Hasan Mahmud et al.
Cardiovascular research, 98(1), 37-46 (2013-01-24)
Suicidal death of erythrocytes (eryptosis) is characterized by cell shrinkage and exposure of phosphatidylserine (PS) residues at the cell surface. Excessive eryptosis may lead to anaemia. We aimed to study the role of eryptosis in heart failure (HF)-associated anaemia. We
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