Skip to Content
Merck
CN

PHR1222

Chlorhexidine acetate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Chlorhexidine diacetate salt, Chlorhexidine diacetate

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C22H30Cl2N10 · 2C2H4O2
CAS Number:
56-95-1
Molecular Weight:
625.55
UNSPSC Code:
41116107
PubChem Substance ID:
329823228
EC Number:
200-302-4
NACRES:
NA.24

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

Clc1ccc(cc1)N\C(=N\C(=NCCCCCCN=C(N)\N=C(\Nc2ccc(cc2)Cl)/N)N)\N.OC(=O)C.OC(=O)C

InChI key

WDRFFJWBUDTUCA-UHFFFAOYSA-N

InChI

1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1111103, traceable to Ph. Eur. C1520000

API family

chlorhexidine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorhexidine acetate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3716 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 2

target_organs

Liver,Teeth

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Formulation development and in vivo evaluation of a novel bioadhesive lozenge containing a synergistic combination of antifungal agents
Codd JE and Deasy PB
International Journal of Pharmaceutics, 173(1-2), 13-24 (1998)
HPLC determination of chlorhexidine acetate and tinidazole in KouS hu solution [J]
Meidi Y and Weigang F
Chinese Journal of Hospital Pharmacy, 2(1-2), 13-24 (1999)
Automated chromatographic determination of chlorhexidine in pharmaceutical preparations
Bailey F, et al.
Journal of Chromatography A, 109(2), 305-312 (1975)
Manikandan Ekambaram et al.
Journal of dentistry, 42(7), 872-882 (2014-02-25)
To evaluate the effect of adjunctive application of ethanol-wet bonding and chlorhexidine (CHX) with a hydrophobic adhesive on bond durability of fibre posts to intraradicular dentine. Ninety-six extracted human teeth with a single root and root canal were prepared for
Synthesis, characterization and antibacterial properties of dihydroxy quaternary ammonium salts with long chain alkyl bromides.
Liu WS, Wang CH, Sun JF, et al.
Chemical Biology & Drug Design, 85(1), 91-97 (2014)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service