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COO/COA

PHR1222

Chlorhexidine acetate

Name: Chlorhexidine acetate
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

Chlorhexidine diacetate salt, Chlorhexidine diacetate

Empirical Formula (Hill Notation):

C₂₂H₃₀Cl₂N₁₀ · 2C₂H₄O₂

CAS Number:

56-95-1

Molecular Weight:

625.55

EC Number:

200-302-4

PubChem Substance ID:

329823228

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 68
traceable to Ph. Eur. C1520000
traceable to USP 1111103

API family

chlorhexidine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)

InChI key

WDRFFJWBUDTUCA-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Sigma-Aldrich

Certified Reference Materials

Chromatography Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorhexidine acetate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3716 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H302 - H315 - H319 - H371 - H410

Precautionary Statements

P260 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P311

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Formulation development and in vivo evaluation of a novel bioadhesive lozenge containing a synergistic combination of antifungal agents

Codd JE and Deasy PB

International Journal of Pharmaceutics, 173(1-2), 13-24 (1998)

HPLC determination of chlorhexidine acetate and tinidazole in KouS hu solution [J]

Meidi Y and Weigang F

Chinese Journal of Hospital Pharmacy, 2(1-2), 13-24 (1999)

Automated chromatographic determination of chlorhexidine in pharmaceutical preparations

Bailey F, et al.

Journal of Chromatography A, 109(2), 305-312 (1975)

Synthesis, characterization and antibacterial properties of dihydroxy quaternary ammonium salts with long chain alkyl bromides.

Liu WS, Wang CH, Sun JF, et al.

Chemical Biology & Drug Design, 85(1), 91-97 (2014)

Effect of chlorhexidine and ethanol-wet bonding with a hydrophobic adhesive to intraradicular dentine.

Manikandan Ekambaram et al.

Journal of dentistry, 42(7), 872-882 (2014-02-25)

To evaluate the effect of adjunctive application of ethanol-wet bonding and chlorhexidine (CHX) with a hydrophobic adhesive on bond durability of fibre posts to intraradicular dentine. Ninety-six extracted human teeth with a single root and root canal were prepared for

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