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PHR1229

Ethylbenzene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Ethylbenzene, NSC 406903, Phenylethane

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About This Item

Linear Formula:
C6H5C2H5
CAS Number:
100-41-4
Molecular Weight:
106.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823235
EC Number:
202-849-4
Beilstein/REAXYS Number:
1901871
MDL number:
MFCD00011647
eCl@ss:
39011201
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1265457

vapor density

3.7 (vs air)

vapor pressure

10 mmHg ( 20 °C), 19 mmHg ( 37.7 °C)

CofA

current certificate can be downloaded

autoignition temp.

810 °F

expl. lim.

6.7 %

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.495 (lit.)

bp

136 °C (lit.)

mp

−95 °C (lit.)

density

0.867 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCc1ccccc1

InChI

1S/C8H10/c1-2-8-6-4-3-5-7-8/h3-7H,2H2,1H3

InChI key

YNQLUTRBYVCPMQ-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards..

Application

Ethylbenzene may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3557 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - STOT RE 2

target_organs

hearing organs

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

71.6 °F - closed cup

flash_point_c

22.0 °C - closed cup

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A validated GC?MS method for the determination and quantification of residual solvents in counterfeit tablets and capsules.
Deconinck E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 70(1-2), 64-70 (2012)
Static headspace gas chromatographic method for quantitative determination of residual solvents in pharmaceutical drug substances according to European Pharmacopoeia requirements.
Otero R, et al.
Journal of Chromatography A, 1057(1-2), 193-201 (2004)
Abby A Li et al.
Neurotoxicology, 31(3), 247-258 (2010-02-23)
The potential for neurotoxicological and immunotoxicological effects of ethylbenzene was studied in young adult Crl:CD(SD) rats following 90-day oral (neurotoxicity) or 28-day inhalation (immunotoxicity) exposures. In the neurotoxicity study, ethylbenzene was administered orally via gavage twice daily at 0, 25
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Global Trade Item Number

SKUGTIN
PHR1229-3X1.2ML04061834414759