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PHR1322

Gabapentin Related Compound A

Name: Gabapentin Related Compound A
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

4,4-Pentamethylene-2-pyrrolidinone, 4,4-PENTAMETHYLENE-2-PYRROLIDONE, Gabapentin Impurity A, 3-Azaspiro[4.5]decan-2-one

Empirical Formula (Hill Notation):

C₉H₁₅NO

CAS Number:

64744-50-9

Molecular Weight:

153.22

MDL number:

MFCD00177938

PubChem Substance ID:

329823307

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0001281
traceable to USP 1287325

API family

gabapentin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

84-89 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C1CC2(CCCCC2)CN1

InChI

1S/C9H15NO/c11-8-6-9(7-10-8)4-2-1-3-5-9/h1-7H2,(H,10,11)

InChI key

JAWPQJDOQPSNIQ-UHFFFAOYSA-N

Related Categories

Analytical Reference Standards

Sigma-Aldrich

Certified Reference Materials

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Gabapentin Related Compound A may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC4059 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

1287303

Gabapentin, United States Pharmacopeia (USP) Reference Standard

1287325

1287347

1287358

1287369

PHR2013

PHR2011

PHR2012

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Product Number

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705578-5MG-PW

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1000309185

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Development and validation of a stability-indicating RP-HPLC-CAD method for gabapentin and its related impurities in presence of degradation products

Ragham PK and Chandrasekhar KB

Journal of Pharmaceutical and Biomedical Analysis, 125, 122-129 (2016)

Gabapentin for once-daily treatment of post-herpetic neuralgia: a review.

Benjamin Beal et al.

Clinical interventions in aging, 7, 249-255 (2012-08-07)

Post-herpetic neuralgia is a neuropathic pain syndrome resulting from an insult to the peripheral and central nervous systems caused by the varicella zoster virus. Spontaneous pain may result in the persistent sensation of burning, tingling, or aching and may be

Gabapentin therapy of hiccups.

Dennis F Thompson et al.

The Annals of pharmacotherapy, 47(6), 897-903 (2013-05-16)

To determine whether gabapentin is effective in the treatment of persistent or intractable hiccups. A search of MEDLINE (1966-March 2013) using the MeSH search terms gabapentin, hiccups, and hiccups/drug therapy was performed. Additional databases searched included Web of Science (1945-March

Clinical development of a once-daily gastroretentive formulation of gabapentin for treatment of postherpetic neuralgia: an overview.

Charles E Argoff et al.

Expert opinion on drug delivery, 9(9), 1147-1160 (2012-07-20)

Gabapentin immediate-release formulations (G-IR) administered three times a day is an efficacious treatment for postherpetic neuralgia (PHN), but its potential benefits may not be fully realized due to tolerability issues as well as its pharmacokinetic (PK) properties such as its

Is there a role for gabapentin in preventing or treating pain following thoracic surgery?

Mustafa Zakkar et al.

Interactive cardiovascular and thoracic surgery, 17(4), 716-719 (2013-07-09)

A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was whether gabapentin, a commonly prescribed neuropathic analgesic and anticonvulsant, is safe and beneficial in patients with post-thoracotomy pain following thoracic surgery. Seventeen

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Articles

Gabapentin Assay and Related Substances Following Ph. Eur. Monograph Using Purospher^® STAR RP-18e HPLC Column

High-performance liquid chromatographic (HPLC) determination of gabapentin and related substances according to Ph. Eur monograph using Purospher^® STAR RP-18 endcapped column, 250 x 4.6 mm, 5 μm.

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