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PHR1455

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Ascorbyl Palmitate

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
L-Ascorbic acid 6-palmitate, 6-O-Palmitoyl-L-ascorbic acid, L-Ascorbyl palmitate, Ascorbic acid 6-palmitate
Empirical Formula (Hill Notation):
C22H38O7
CAS Number:
137-66-6
Molecular Weight:
414.53
Beilstein:
96552
EC Number:
205-305-4
MDL number:
MFCD00005377
PubChem Substance ID:
329822615
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0000800
traceable to USP 1043105

API family

ascorbyl palmitate

CofA

current certificate can be downloaded

packaging

pkg of 2 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

115-118 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)COC(=O)CCCCCCCCCCCCCCC

InChI

1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1

InChI key

QAQJMLQRFWZOBN-LAUBAEHRSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ascorbyl Palmitate is a lipophilic ascorbic acid derivative, used as an antioxidant in both food and cosmetics industries.

Application

Ascorbyl Palmitate may be used as a standard for the determination of the analyte in vegetable oils, edible fats and commercial cosmetic cream by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7810 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia
Huang MT, et al.
Cancer letters, 64(2), 117-121 (1992)
Development of ascorbyl palmitate nanocrystals applying the nanosuspension technology
Teeranachaideekul V, et al.
International Journal of Pharmaceutics, 354(1-2), 227-234 (2008)
Simultaneous HPLC determination of multiple components in a commercial cosmetic cream
Sottofattori E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 18(1-2), 213-217 (1998)
Simultaneous determination of ascorbyl palmitate and nine phenolic antioxidants in vegetable oils and edible fats by HPLC
Perrin C and Meyer L
Journal of the American Oil Chemists' Society, 80(2), 115-118 (2003)
Alex C M Oliveira et al.
Nutrients, 6(5), 2059-2076 (2014-05-27)
The beneficial health effects of a diet rich in n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) have been extensively researched in recent years. Marine oils are an important dietary source of n-3 LC-PUFA, being especially rich in two of
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