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PHR1460

Supelco

Choline Bitartrate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
2-(Hydroxyethyl)trimethylammonium bitartrate, Choline bitartrate
Empirical Formula (Hill Notation):
C9H19NO7
CAS Number:
Molecular Weight:
253.25
EC Number:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1133536

storage temp.

2-30°C

SMILES string

[O-]C([C@H](O)[C@@H](O)C(O)=O)=O.C[N+](C)(C)CCO

InChI

1S/C5H14NO.C4H6O6/c1-6(2,3)4-5-7;5-1(3(7)8)2(6)4(9)10/h7H,4-5H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/q+1;/p-1/t;1-,2-/m.1/s1

InChI key

QWJSAWXRUVVRLH-LREBCSMRSA-M

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Choline Bitartrate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography (LC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Acyl group acceptor

Substrates

Choline acetyltransferase substrate

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2888 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Choline Bitartrate
USP42-NF37
United States Pharmacopeia/National Formulary, 30(3), 4839-4839 (2019)
Maria Kharitonova et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 29, 227-234 (2014-08-16)
Magnesium (Mg) deficiency is implicated in the development of numerous disorders of the cardiovascular system. Moreover, the data regarding the efficacy of different magnesium compounds in the correction of impaired functions due to low magnesium intake are often fragmentary and
Vipen Batra et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 46-54 (2014-04-12)
The objective of this study was to examine the effect of (60)Co-gamma (γ) radiation on modulation of genomic DNA methylation, if any, of mice maintained (6 weeks) on normal control diet (NCD) and L-methionine supplemented diet (MSD). To elucidate the
Naoki Tanaka et al.
Biochimica et biophysica acta, 1841(11), 1596-1607 (2014-09-03)
Methionine- and choline-deficient diet (MCD) is a model for nonalcoholic steatohepatitis (NASH) in rodents. However, the mechanism of NASH development by dietary methionine/choline deficiency remains undetermined. To elucidate the early metabolic changes associated with MCD-NASH, serum metabolomic analysis was performed
Tohru Sakai et al.
Journal of nutritional science and vitaminology, 61(1), 73-78 (2015-05-23)
Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects

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