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Merck
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PHR1587

Thimerosal

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Thimerosal, 2-(Ethylmercuriomercapto)benzoic acid sodium salt, Ethylmercurithiosalicylic acid sodium salt, Mercury-([o-carboxyphenyl]thio)ethyl sodium salt, Sodium ethylmercurithiosalicylate

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About This Item

Linear Formula:
2-(C2H5HgS)C6H4CO2Na
CAS Number:
54-64-8
Molecular Weight:
404.81
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823493
EC Number:
200-210-4
Beilstein/REAXYS Number:
8169555
MDL number:
MFCD00013062

Key Documents

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Product Name

Thimerosal, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

SMILES string

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000109
traceable to USP 1659000

API family

thimerosal

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

234-237 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Other Notes

To see an example of a Certificate of Analysis for this material enter LRAA6959 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thimerosal may be used as a pharmaceutical reference standard for the quantification of the analyte in ophthalmic solutions using spectrophotometric technique.

Biochem/physiol Actions

Thimerosal is a sulfhydryl (thiol) oxidizing reagent capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins such as PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na++K+ dependent ATPases.

Disclaimer

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

General description

Thimerosal belongs to the group of alkyl mercury compounds. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

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Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

target_organs

Kidney

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Association between thimerosal-containing vaccine and autism
Hviid A, et al.
JAMA : The Journal of the American Medical Association, 290(13), 1763-1766 (2003)
Simultaneous spectrophotometric-multivariate calibration determination of several components of ophthalmic solutions: phenylephrine, chloramphenicol, antipyrine, methylparaben and thimerosal
Collado.SM, et al.
Talanta, 52(5), 909-920 (2000)
Autism Res advances (2007)

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