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Merck
CN

04231

Calcium phosphate dibasic dihydrate

puriss., meets analytical specification of Ph. Eur., BP, USP, 98-102.5%

Synonym(s):

Calcium hydrogen phosphate dihydrate

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About This Item

Linear Formula:
CaHPO4 · 2H2O
CAS Number:
Molecular Weight:
172.09
PubChem Substance ID:
UNSPSC Code:
51101500
NACRES:
NA.21
EC Number:
231-826-1
MDL number:
Assay:
98-102.5%
Form:
powder
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InChI key

XAAHAAMILDNBPS-UHFFFAOYSA-L

InChI

1S/Ca.H3O4P.2H2O/c;1-5(2,3)4;;/h;(H3,1,2,3,4);2*1H2/q+2;;;/p-2

grade

puriss.

assay

98-102.5%

form

powder

quality

meets analytical specification of Ph. Eur., BP, USP

impurities

organic volatile impurities, complies, residual solvents, complies, ≤0.003% heavy metals (as Pb), ≤0.1% insoluble in HCl

loss

24.5-26.5% loss on ignition, 800 °C

anion traces

carbonate (CO32-): in accordance, chloride (Cl-): ≤200 mg/kg, fluoride (F-): ≤50 mg/kg, sulfate (SO42-): ≤3000 mg/kg

cation traces

As: ≤1 mg/kg, Ba:, in accordance (Ph Eur), Ba:, in accordance (USP), Fe: ≤300 mg/kg

Quality Level

Application


  • Simultaneous Regulation of the Mechanical/Osteogenic Capacity of Brushite Calcium Phosphate Cement by Incorporating with Poly(ethylene glycol) Dicarboxylic Acid: This research investigates enhancing brushite calcium phosphate cements by adding poly(ethylene glycol) dicarboxylic acid to improve mechanical properties and osteogenic capabilities, applicable in bone regeneration and implant materials. (Gao et al., 2024).

  • Biosurfactant-Assisted Cu Doping of Brushite Coatings: Explores the structural and biofunctional enhancements of brushite coatings through copper doping facilitated by biosurfactants, which could revolutionize surface treatments for biocompatible implants and devices. (Siva Prasad et al., 2024).

  • Self-Healing Micro Arc Oxidation and Dicalcium Phosphate Dihydrate Double-Passivated Coating on Magnesium Membrane for Enhanced Bone Integration Repair: This study highlights the application of calcium phosphate dibasic dihydrate in developing protective coatings on magnesium-based implants, significantly advancing orthopedic and dental implant technologies. (Wu et al., 2024).

  • Physiologically Engineered Porous Titanium/Brushite Scaffolds for Critical-Size Bone Defects: Details the design and fabrication of novel scaffolds for treating large bone defects, utilizing a combination of titanium and brushite, highlighting its potential in reconstructive surgery and regenerative medicine. (Abdulaziz et al., 2023).

  • Mechanochemical Synthesis of Cerium Chlorapatite from a Mixture of Cerium Chloride Heptahydrate, Dicalcium Phosphate Dihydrate, and Calcium Hydroxide for Biomedical Application: Focuses on the innovative production of cerium chlorapatite using dicalcium phosphate dihydrate, showcasing its potential in biomedical engineering, especially in drug delivery and tissue engineering. (Otsuka et al., 2024).

pictograms

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Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable


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J M Lausier et al.
Journal of pharmaceutical sciences, 66(11), 1636-1637 (1977-11-01)
The aging of direct compression tablets made using dibasic calcium phosphate dihydrate as the tablet matrix was investigated over 16 weeks. The formula included 6% amaranth as a dye tracer. Two sets of stress storage conditions were used: 25 degrees
Moreton, R. C.
Chemical & Pharmaceutical Bulletin, 868-870 (1996)
Sarsvatkumar Patel et al.
International journal of pharmaceutics, 403(1-2), 109-114 (2010-11-03)
The aim of the study was to develop, compare and validate predictive model for mechanical property of binary systems. The mechanical properties of binary mixtures of ibuprofen (IBN) a poorly compressible high dose drug, were studied in presence of different
S Tadier et al.
Acta biomaterialia, 7(4), 1817-1826 (2010-12-15)
In part I of this study we aim to evaluate and control the characteristics of the powders constituting the solid phase of a vaterite CaCO(3)-dicalcium phosphate dihydrate cement using a co-grinding process and to determine their impact on cement setting
Dong Chen et al.
Journal of orthopaedic surgery and research, 6, 56-56 (2011-11-08)
Uncemented fixation of components in joint arthroplasty is achieved primarily through de novo bone formation at the bone-implant interface and establishment of a biological and mechanical interlock. In order to enhance bone-implant integration osteoconductive coatings and the methods of application

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