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Merck
CN

31462

Nickel(II) chloride hexahydrate

puriss. p.a., ≥98%

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About This Item

Linear Formula:
NiCl2 · 6H2O
CAS Number:
Molecular Weight:
237.69
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352302
MDL number:
Assay:
≥98%
Form:
powder or crystals
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InChI

1S/2ClH.Ni.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2

SMILES string

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].Cl[Ni]Cl

InChI key

LAIZPRYFQUWUBN-UHFFFAOYSA-L

grade

puriss. p.a.

assay

≥98%

form

powder or crystals

reaction suitability

reagent type: catalyst
core: nickel

pH

4-7 (20 °C, 5%)

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤50 mg/kg, Cd: ≤10 mg/kg, Co: ≤100 mg/kg, Cu: ≤10 mg/kg, Fe: ≤20 mg/kg, Mg: ≤10 mg/kg, Na: ≤50 mg/kg, Pb: ≤10 mg/kg, Zn: ≤10 mg/kg

storage temp.

room temp

Quality Level

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General description

Nickel(II) chloride hexahydrate is a hydrated nickel salt. Its crystals were monoclinic and structure was investigated by X-ray single crystal method.

Application

Nickel(II) chloride hexahydrate may be employed as a catalyst in the high yield synthesis of tetra-substituted pyrrole derivatives. It may be used for the conversion of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers to the corresponding hydroxyl compounds.

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A Inhalation - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1 Inhalation

target_organs

Lungs

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Regulatory Information

危险化学品
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The Crystal Structure of Nickel Chloride Hexahydrate, NiCl2.6H2O.
Mizuno J.
Journal of the Physical Society of Japan, 16(8), 1571-1580 (1961)
Synthesis of tetra-substituted pyrroles, a potential phosphodiesterase 4B inhibitor, through nickel (II) chloride hexahydrate catalyzed one-pot four-component reaction.
Khan AT, et al.
Tetrahedron Letters, 53(32), 4145-4150 (2012)
A catalytic amount of nickel (II) chloride hexahydrate and 1, 2-ethanedithiol is a good combination for the cleavage of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers.
Khan AT, et al.
Tetrahedron Letters, 45(52), 9617-9621 (2004)
Ritu Tyagi et al.
Journal of applied toxicology : JAT, 33(2), 134-141 (2011-09-20)
Heavy metals are known for their associated nephrotoxicity and nickel is no exception. An integrated metabonomic approach, based on high-resolution (1) H NMR spectroscopy, was applied to determine the acute biochemical effects of NiCl(2) on the renal tissues of rats.
Steven J Ryan et al.
PloS one, 7(4), e35320-e35320 (2012-05-09)
The basolateral complex of the amygdala (BLA) is a critical component of the neural circuit regulating fear learning. During fear learning and recall, the amygdala and other brain regions, including the hippocampus and prefrontal cortex, exhibit phase-locked oscillations in the

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