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Merck
CN

A1466

N-Acetyl-Trp-Glu-His-Asp-al

≥80% (HPLC), powder

Synonym(s):

Ac-WEHD-CHO

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About This Item

Empirical Formula (Hill Notation):
C28H33N7O9
CAS Number:
189275-71-6
Molecular Weight:
611.60
MDL number:
MFCD01318860
UNSPSC Code:
12352200
PubChem Substance ID:
329770707

Key Documents

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Assay

≥80% (HPLC)

form

powder

color

white

solubility

H2O: 1 mg/mL

storage temp.

−20°C

SMILES string

CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N[C@@H](CC(O)=O)C=O

InChI

1S/C28H33N7O9/c1-15(37)32-22(8-16-11-30-20-5-3-2-4-19(16)20)28(44)34-21(6-7-24(38)39)26(42)35-23(9-17-12-29-14-31-17)27(43)33-18(13-36)10-25(40)41/h2-5,11-14,18,21-23,30H,6-10H2,1H3,(H,29,31)(H,32,37)(H,33,43)(H,34,44)(H,35,42)(H,38,39)(H,40,41)/t18-,21-,22-,23-/m0/s1

InChI key

ZSZYUXBVDPGGGX-QGQQZZQASA-N

Biochem/physiol Actions

Very potent caspase 1 and 5 inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315

Hazard Classifications

Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBD6025V
1408999
098H1189

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Daichi Sadatomi et al.
Journal of biochemistry, 161(6), 503-512 (2017-01-18)
The NLRP3 inflammasome plays a critical role in the processing and release of inflammatory cytokines, such as interleukin-1β (IL-1β) and IL-18. Accumulating evidence suggests that mitochondria are common mediators of NLRP3 inflammasome activation induced by a wide range of inflammatory

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