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Merck
CN

C3130

Cortisone 21-acetate

synthetic (organic), ≥99%, corticosteroid, powder

Synonym(s):

17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate

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About This Item

Empirical Formula (Hill Notation):
C23H30O6
CAS Number:
50-04-4
Molecular Weight:
402.48
NACRES:
NA.77
PubChem Substance ID:
24278306
UNSPSC Code:
51111800
EC Number:
200-006-5
MDL number:
MFCD00003609
Beilstein/REAXYS Number:
2067543
Assay:
≥99%
Form:
powder
Quality level:
200

Key Documents

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Product Name

Cortisone 21-acetate, ≥99%

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥99%

form

powder

mp

237-240 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1

InChI key

ITRJWOMZKQRYTA-RFZYENFJSA-N

Gene Information

human ... FNTA(2339), NR3C1(2908)

Related Categories

General description

Cortisone 21-acetate is a prodrug, which has glucocorticoid and mineralocorticoid properties. It is used as a therapeutic option for glucocorticoid replacement.

Application

Cortisone 21-acetate has been used to study its effects in metastasis and phagocytic activity.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361d

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000494919
0000494919
0000495349
0000495349
0000478797

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Replacement therapy in Addison?s disease
Lovaas K and Husebye ES
Expert Opinion on Pharmacotherapy (2003)
D M Dixon et al.
Infection and immunity, 57(5), 1452-1456 (1989-05-01)
We report on a model of primary pulmonary aspergillosis occurring after intranasal instillation of concentrated suspensions of conidia of Aspergillus fumigatus in immunocompromised mice. Unconcentrated suspensions of inoculum contained ca. 2 x 10(7) conidia per ml (1x). These suspensions were
Foye's Principles of Medicinal Chemistry (2008)
Lin Lin et al.
The Journal of infectious diseases, 205(2), 337-347 (2011-11-30)
Activated transfected killer (ATAK) cells are immortal phagocytes transfected with a luminescence reporter that effectively treat lethal infections in neutropenic mice. Their in vivo trafficking, lifespan, and immunogenicity are unknown. Mice were made neutropenic; infected or not with Staphylococcus aureus
Ana Gil-Bona et al.
Journal of proteomics, 127(Pt B), 340-351 (2015-06-19)
The ability to switch from yeast to hyphal growth is essential for virulence in Candida albicans. The cell surface is the initial point of contact between the fungus and the host. In this work, a free-gel proteomic strategy based on
View All Related Papers

Global Trade Item Number

SKUGTIN
C3130-5G04061832867045
C3130-10G04061832867021
C3130-1G04061833485330
C3130-25G04061832867038

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