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Merck
CN

L1026

Lidocaine

Na+ channel blocker, solid

Synonym(s):

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine

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About This Item

Empirical Formula (Hill Notation):
C14H22N2O
CAS Number:
137-58-6
Molecular Weight:
234.34
NACRES:
NA.77
PubChem Substance ID:
24896272
UNSPSC Code:
12352200
EC Number:
205-302-8
MDL number:
MFCD00026733
Form:
solid
Quality level:
200

Key Documents

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Product Name

Lidocaine, analytical standard

grade

analytical standard

Quality Level

200

form

solid

packaging

vial of 200 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤0.5% Total Organic Impurities (Lidocaine related compound H ≤0.10%


2,6-Dimethylaniline ≤0.01%


Any unspecified impurity ≤0.10%


Total impurities ≤0.5%)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

SMILES string

CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)

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General description

Lidocaine is an amide anesthetic, which is used to treat ventricular arrhythmias. It lowers cardiac automaticity and myocardial conduction. Lidocaine inhibits the generation and conduction of nerve impulses. It has an anticonvulsant effect.

Application

Lidocaine has been used to examine its effects in inhibiting lymph flow and protection against envenomation. It has also been used to assess its efficacy as an anti-tussive agent.

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.
Na+ channel blocker; class IB antiarrhythmic.

Packaging

Supplied in amber screw-cap vials

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000490804
0000490804
SLCF7788
SLBV4350
SLBJ7206V

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Key Issues in Plastic and Cosmetic Surgery (1999)
Pharmacological approaches that slow lymphatic flow as a snakebite first aid
van Helden DF, et al.
PLoS Neglected Tropical Diseases, 8(2), e2722-e2722 (2014)
Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs
Venkatasamy R, et al.
Journal of Pharmacological and Toxicological Methods, 61(2), 157-162 (2010)
Seizures in Critical Care: A Guide to Diagnosis and Therapeutics (2008)
Effect of lidocaine on ventricular arrhythmias in patients with coronary heart disease
Gianelly R, et al.
The New England Journal of Medicine, 277(23), 1215-1219 (1967)
View All Related Papers

Global Trade Item Number

SKUGTIN
L1026-1VL04061833949177

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