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Merck
CN

AV32859

Sigma-Aldrich

Anti-KLF8 (AB2) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Kruppel-like factor 8

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

39 kDa

species reactivity

human, dog

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_009181

UniProt accession no.

O95600

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... KLF8(11279)

General description

KLF8 functions as a downstream target of focal adhesion kinase (FAK) during cell cycle progression and cyclin D1 regulation. It has also been implicated in oncogenic transformation. Furthermore, KLF8 is known to have prognostic implications in gastric adenocarcinomas.
Rabbit Anti-KLF8 (AB2) antibody recognizes human, mouse, and rat KLF8.

Immunogen

Synthetic peptide directed towards the middle region of human KLF8

Application

Rabbit Anti-KLF8 (AB2) antibody can be used for western blot applications at a concentration of 0.5μg/ml. It has also been used for immunohistochemistry applications.

Biochem/physiol Actions

KLF8 is abnormally expressed in female patients with X autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: LEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQGGESLDLKRRRIHQ

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC2337

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Jihe Zhao et al.
Molecular cell, 11(6), 1503-1515 (2003-06-25)
Focal adhesion kinase (FAK) is an important mediator of integrin signaling in the regulation of cell adhesion, migration, survival, and proliferation. Here we report the identification of the transcription factor KLF8 as a target of FAK in cell cycle regulation.
Li-Sung Hsu et al.
Annals of diagnostic pathology, 18(2), 74-77 (2014-01-28)
Krűppel-like factor 8 (KLF8) is important in cell proliferation, epithelial-to-mesenchymal transition, cell migration, and invasion. Gastric adenocarcinoma is among the leading causes of cancer-related death in the world. In this study, the clinicopathologic correlation of KLF8 expression with gastric adenocarcinoma
X Wang et al.
Oncogene, 26(3), 456-461 (2006-07-13)
Kruppel-like factor 8 (KLF8) is a member of the family of KLF transcription factors. Several KLF members have been shown to play a role in oncogenesis. We have previously demonstrated that KLF8 mediates cell cycle progression downstream of focal adhesion

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