AV32859
Anti-KLF8 (AB2) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-Kruppel-like factor 8
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
39 kDa
species reactivity
human, dog
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... KLF8(11279)
Related Categories
General description
KLF8 functions as a downstream target of focal adhesion kinase (FAK) during cell cycle progression and cyclin D1 regulation. It has also been implicated in oncogenic transformation. Furthermore, KLF8 is known to have prognostic implications in gastric adenocarcinomas.
Rabbit Anti-KLF8 (AB2) antibody recognizes human, mouse, and rat KLF8.
Rabbit Anti-KLF8 (AB2) antibody recognizes human, mouse, and rat KLF8.
Immunogen
Synthetic peptide directed towards the middle region of human KLF8
Application
Rabbit Anti-KLF8 (AB2) antibody can be used for western blot applications at a concentration of 0.5μg/ml. It has also been used for immunohistochemistry applications.
Biochem/physiol Actions
KLF8 is abnormally expressed in female patients with X autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: LEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQGGESLDLKRRRIHQ
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Li-Sung Hsu et al.
Annals of diagnostic pathology, 18(2), 74-77 (2014-01-28)
Krűppel-like factor 8 (KLF8) is important in cell proliferation, epithelial-to-mesenchymal transition, cell migration, and invasion. Gastric adenocarcinoma is among the leading causes of cancer-related death in the world. In this study, the clinicopathologic correlation of KLF8 expression with gastric adenocarcinoma
X Wang et al.
Oncogene, 26(3), 456-461 (2006-07-13)
Kruppel-like factor 8 (KLF8) is a member of the family of KLF transcription factors. Several KLF members have been shown to play a role in oncogenesis. We have previously demonstrated that KLF8 mediates cell cycle progression downstream of focal adhesion
Jihe Zhao et al.
Molecular cell, 11(6), 1503-1515 (2003-06-25)
Focal adhesion kinase (FAK) is an important mediator of integrin signaling in the regulation of cell adhesion, migration, survival, and proliferation. Here we report the identification of the transcription factor KLF8 as a target of FAK in cell cycle regulation.
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