SUP-T1

SUP-T1 has been used in a study targeting B-cell neoplasia with T-cell receptors recognizing a cluster of differentiation 20 (CD20)-derived peptide on patient-specific human leucocyte antigen (HLA). Existing appl-SUP-T1 cells have been used for growth of HIV-1.

Cells have been used for growth of HIV-1

Derived from a Malignant pleural effusion taken from an eight year old caucasian male with T cell lymphoblastic lymphoma. These cells are E-rosette, Leu 5, OKT9 and CALLA negative. They also express β2M, Leu 1, 2, 3a, 4, 6, 9 and OKT10 antigens and are CD4 positive. These cells are negative for Tac, HLA-DR and surface immunoglobulin.

Human T cell lymphoblastic Lymphoma

Maintain cultures between 2x100,000 to 2x1,000,000 cells/ml 5% CO₂; 37°C.

RPMI 1640 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).

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This cell line is part of the European Collection of Authenticated Cell Cultures (ECACC), an international repository managed by the United Kingdom Health Security Agency (UKHSA). No licensing agreement is required when either this cell line or the DNA extracted from it are used for internal research purposes only. Any other use of these products is prohibited without the express written permission of UKHSA. Inquiries regarding authorized use of this cell line or its genomic DNA may be directed to culturecollections@ukhsa.gov.uk.