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Merck
CN

EHU095741

MISSION® esiRNA

targeting human DMAP1

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NACRES:
NA.51
UNSPSC Code:
41105324

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lyophilized powder

description

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product line

MISSION®

esiRNA cDNA target sequence

AAGTTGGGCTCCAAGAAGGTGCGGCCTTGGAAGTGGATGCCATTCACCAACCCGGCCCGCAAGGACGGAGCAATGTTCTTCCACTGGCGACGTGCAGCGGAGGAGGGCAAGGACTACCCCTTTGCCAGGTTCAATAAGACTGTGCAGGTGCCTGTGTACTCGGAGCAGGAGTACCAGCTTTATCTCCACGATGATGCTTGGACTAAGGCAGAAACTGACCACCTCTTTGACCTCAGCCGCCGCTTTGACCTGCGTTTTGTTGTTATCCATGACCGGTATGACCACCAGCAGTTCAAGAAGCGT

Ensembl | human accession no.

ENSG00000178028

NCBI accession no.

NM_001034024

shipped in

ambient

storage temp.

−20°C

Quality Level

100

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General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Wenhuan Guo et al.
The Prostate, 75(9), 976-987 (2015-03-27)
ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor in the prostate. However, the mechanisms underlying tumor suppressive function of EAF2 are still largely unknown. Identification of factors capable of modulating EAF2 function will help elucidate the mechanisms underlying EAF2
Liquan Cai et al.
Biochemical and biophysical research communications, 447(2), 292-298 (2014-04-15)
The tumor suppressor EAF2 is regulated by androgen signaling and associated with prostate cancer. While EAF2 and its partner ELL have been shown to be members of protein complexes involved in RNA polymerase II transcriptional elongation, the biologic roles for

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