H2529
α-Hydroxytriazolam
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About This Item
Empirical Formula (Hill Notation):
C17H12Cl2N4O
CAS Number:
Molecular Weight:
359.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2
SMILES string
OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12
InChI key
BHUYWUDMVCLHND-UHFFFAOYSA-N
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
Quality Level
Biochem/physiol Actions
Triazolam metabolite
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Jin, L., et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 654, 77-77 (1994)
F S Eberts et al.
Clinical pharmacology and therapeutics, 29(1), 81-93 (1981-01-01)
Triazolam (T) is a new, potent hypnotic with a short duration of action in man. After an 0.88-mg oral dose of T-14C in six male subjects, mean recovery of 14C radioactivity was 85% in urine and 8% in feces. The
Dong-Liang Lin et al.
Journal of analytical toxicology, 29(2), 118-123 (2005-05-21)
As an approved medicinal product and reportedly an abused substance that have been associated with death and "considered to be a factor...of impaired driving, sexual assault, and other violent crimes", triazolam is controlled at the same level (Level III) as
Qiran Sun et al.
Journal of analytical toxicology, 34(2), 89-94 (2010-03-13)
A sensitive liquid chromatography-tandem mass spectrometry method is presented for determination of triazolam and alpha-hydroxytriazolam in guinea pig hair after a single dose of triazolam. Eighteen guinea pigs were divided into three dosage groups (10, 100, and 500 microg/kg) and
Dora Farkas et al.
Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)
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