H2529
α-Hydroxytriazolam
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About This Item
Empirical Formula (Hill Notation):
C17H12Cl2N4O
CAS Number:
Molecular Weight:
359.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2
SMILES string
OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12
InChI key
BHUYWUDMVCLHND-UHFFFAOYSA-N
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
Quality Level
Biochem/physiol Actions
Triazolam metabolite
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Jin, L., et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 654, 77-77 (1994)
Qiran Sun et al.
Journal of analytical toxicology, 34(2), 89-94 (2010-03-13)
A sensitive liquid chromatography-tandem mass spectrometry method is presented for determination of triazolam and alpha-hydroxytriazolam in guinea pig hair after a single dose of triazolam. Eighteen guinea pigs were divided into three dosage groups (10, 100, and 500 microg/kg) and
Dora Farkas et al.
Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)
Fumio Moriya et al.
Legal medicine (Tokyo, Japan), 5 Suppl 1, S91-S95 (2003-08-26)
A 57-year-old man was found dead lying down in a bamboo thicket. Moderate to severe petechiae were present on his conjunctivae, buccal mucosa, and laryngeal mucosa at autopsy. Cardiac chambers contained a normal volume of fluid blood. Moderate atherosclerosis and
A D Fraser et al.
Journal of analytical toxicology, 16(6), 347-350 (1992-11-01)
Triazolam is a very short-acting triazolobenzodiazepine with sedative-hypnotic properties. Approximately 2% of an oral dose is excreted unchanged in the urine. The major urinary metabolite is alpha-hydroxytriazolam glucuronide (70% of the dose). The objective of this study was to characterize
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