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H2529

α-Hydroxytriazolam

Name: α-Hydroxytriazolam
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₂Cl₂N₄O

CAS Number:

37115-45-0

Molecular Weight:

359.21

NACRES:

NA.77

PubChem Substance ID:

24895508

UNSPSC Code:

12352200

MDL number:

MFCD00467159

Quality level:

200

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Properties

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

Quality Level

200

SMILES string

OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12

InChI

1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2

InChI key

BHUYWUDMVCLHND-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Triazolam metabolite

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H361fd

pcodes

P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Jin, L., et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 654, 77-77 (1994)

Urinary excretion profiles of two major triazolam metabolites, alpha-hydroxytriazolam and 4-hydroxytriazolam.

Kenji Tsujikawa et al.

Journal of analytical toxicology, 29(4), 240-243 (2005-06-25)

The objective of this study was to examine urinary excretion profiles of two major triazolam metabolites, alpha-hydroxytriazolam (alpha-OHTRZ) and 4-hydroxytriazolam (4-OHTRZ) in humans. Urine samples were collected from three healthy male volunteers who had been previously administered single 0.25- and

Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice.

Dora Farkas et al.

Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)

The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)

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Global Trade Item Number

SKU	GTIN
H2529-5MG	04061833792339