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PLA0003

Sigma-Aldrich

Rabbit anti-Phospho BRCA1 (S1280) Antibody, Affinity Purified

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Synonym(s):
complementation group S, regulatory subunit 53, truncated breast cancer type 1 susceptibility protein, breast cancer 1, early onset, truncated BRCA1, breast and ovarian cancer sususceptibility protein 1, BRCC1, RING finger protein 53, truncated breast and ovarian cancer sususceptibility protein 1, Fanconi anemia, RNF53, early onset breast cancer 1, truncated breast and ovarian cancer susceptibility protein 1, FANCS, PNCA4, protein phosphatase 1, BRCAI, BRCA1/BRCA2-containing complex, PSCP, breast and ovarian cancer susceptibility protein 1, IRIS, BROVCA1, subunit 1, PPP1R53
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

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species reactivity

human

technique(s)

immunoprecipitation (IP): 2.5 μg/mg
western blot: 1:1,000- 1:10,000

accession no.

NP_009225.1

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... BRCA1(672)

Immunogen

Immunogen for PLA0003 was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1280 according to the numbering given in entry NP_009225.1.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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