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All Photos(2)

PLA0133

Sigma-Aldrich

Rabbit anti-PTEN Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
BZS, 4, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, TEP1, mitochondrial PTENalpha, phosphatase and tensin-like protein, MMAC1, Phosphatase and tensin homolog, mutated in multiple advanced cancers 1, MHAM, GLM2, mitochondrial phosphatase and tensin protein alpha, 10q23del, CWS1, DEC, phosphatidylinositol-3, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, PTEN1
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

mouse, human

technique(s)

immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_000305.2

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... PTEN(5728)

Immunogen

The epitope recognized by PLA0133 maps to a region between residue 350 and the C-terminus (residue 403) of human phosphatase and tensin homolog using the numbering given in entry NP_000305.2 (GeneID 5728).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

PTEN (phosphatase and tensin homolog) is a phosphatidylinositol-3,4,5-triphosphate 3-phosphatase that has been identified as a tumor suppressor. PTEN is a dual specificity tyrosine and serine/threonine phosphatase that preferentially dephosphorylates phosphoinositide substrates and negatively regulates the AKT/PKB signaling pathway. Through its action, PTEN has been shown to modulate cell cycle progression, cell survival, cell migration, cell adhesion, and insulin signaling.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Takashi Sumita et al.
American journal of physiology. Endocrinology and metabolism, 307(1), E47-E60 (2014-05-16)
Phosphatase and tensin homolog (PTEN) dephosphorylates phosphatidylinositol (PI) 3,4,5-triphosphate and antagonizes PI 3-kinase. Insulin acts in the mediobasal hypothalamus (MBH) to not only suppress food intake and weight gain but also improve glucose metabolism via PI 3-kinase activation. Thus, the
Lene Rask et al.
Cellular oncology (Dordrecht), 37(3), 215-227 (2014-07-17)
Therapeutic decisions in breast cancer are increasingly guided by prognostic and predictive biomarkers. Non-protein-coding microRNAs (miRNAs) have recently been found to be deregulated in breast cancers and, in addition, to be correlated with several clinico-pathological features. One of the most
Ioannis Kalogiannidis et al.
Archives of gynecology and obstetrics, 290(6), 1231-1237 (2014-07-16)
To define the prognostic significance of HER-2/neu and PTEN expression in patients with endometrioid (type I) endometrial cancer. Seventy-seven patients with endometrioid endometrial carcinoma were included in the study, in a period between 1996 and 2009. Patients with coexisting malignancy
Y Dong et al.
Oncogene, 33(38), 4632-4642 (2013-10-22)
Cancer cells acquire several traits that allow for their survival and progression, including the ability to evade the host immune response. However, the mechanisms by which cancer cells evade host immune responses remain largely elusive. Here we study the phenomena
Yongjun Cha et al.
Anticancer research, 34(8), 4275-4280 (2014-07-31)
To identify immunohistochemical (IHC) features associated with sensitivity to lapatinib-plus-capecitabine (LX) and resistance to trastuzumab in human epidermal growth factor receptor (HER)-2-positive metastatic breast cancer. Expression levels of estrogen receptor, progesterone receptor, epidermal growth factor receptor, HER2, HER3/phosphorylated HER3 (pHER3)

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