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Merck
CN

PLA0171

Rabbit anti-SMRT Antibody, Affinity Purified

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Synonym(s):

CTG repeat protein 26, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, Silencing mediator of retinoic acid and thyroid hormone receptor, T3 receptor-associating factor, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor co-repressor 2, retinoic-acid-receptor-associated corepressor, silencing mediator for retinoid and thyroid hormone receptors, thyroid-

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
1

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

immunoprecipitation (IP): 2-5 μg/mg, western blot: 1:2,000- 1:10,000

accession no.

AAD20946.1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rabbit ... SMRT(9612)

Immunogen

The epitope recognized by PLA0171 maps to a region between residue 1525 and 1575 of human silencing mediator of retinoic acid and thyroid hormone receptor alpha using the numbering given in entry AAD20946.1 (GeneID 9612).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

SMRT (silencing mediator of retinoid and thyroid hormone receptor) mediates gene repression by interacting with nuclear receptors such as the thyroid hormone receptor, retinoic acid receptor, progesterone receptor, androgen receptor, estrogen receptor, and glucocorticoids receptor. SMRT mediates repression by associating with SIN3A/B and the histone deacetylases, HDAC1 and HDAC2, and promoting the formation of repressive chromatin structures.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
1

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Xiumei Zhang et al.
PloS one, 14(5), e0217181-e0217181 (2019-05-24)
MiR-873/CDK3 has been shown to play a critical role in ERα signaling and tamoxifen resistance. Thus, targeting this pathway may be a potential therapeutic approach for the treatment of ER positive breast cancer especially tamoxifen resistant subtype. Here we report

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