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PZ0114

PD-166866

Name: PD-166866
Brand: SIGMA

≥98% (HPLC), FGF-1 receptor tyrosine kinase (FGFR1) inhibitor

别名:

1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₄N₆O₃

化学文摘社编号:

192705-79-6

分子量:

396.44

UNSPSC Code:

51111800

PubChem Substance ID:

329823706

NACRES:

NA.77

MDL number:

MFCD12922514

Assay:

≥98% (HPLC)

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属性

产品名称

PD-166866, ≥98% (HPLC)

assay

≥98% (HPLC)

color

off-white to light tan

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc(OC)cc(c1)-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C

InChI

1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)

InChI key

NHJSWORVNIOXIT-UHFFFAOYSA-N

说明

Biochem/physiol Actions

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC₅₀ = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c