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PZ0117

PF-573228

Name: PF-573228
Brand: SIGMA

≥95% (HPLC), FAK inhibitor, powder

Synonym(s):

6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one, PF-228

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₀F₃N₅O₃S

CAS Number:

869288-64-2

Molecular Weight:

491.49

UNSPSC Code:

12352200

PubChem Substance ID:

329823709

NACRES:

NA.77

MDL number:

MFCD11519967

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

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Product Name

PF-573228, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1

InChI

1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)

InChI key

HESLKTSGTIBHJU-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000385750

0000187302

0000135660

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KLF8 promotes invasive outgrowth of breast cancer by inducing filopodium-like protrusions via CXCR4.

Debarati Mukherjee et al.

American journal of translational research, 14(2), 1220-1233 (2022-03-12)

Post-therapeutic relapse remains the biggest challenge to breast cancer management. The re-initiation of proliferation of dormant tumor cells in either metastatic or primary tumor location marks the final rate-limiting step of malignancy and mortality. The underlying molecular mechanisms remain poorly

Merging of ventral fibers at adhesions drives the remodeling of cellular contractile systems in fibroblasts.

Shwetha Narasimhan et al.

Cytoskeleton (Hoboken, N.J.), 79(9-11), 81-93 (2022-08-24)

Ventral stress fibers (VSFs) are contractile actin fibers dynamically attached to cell-matrix focal adhesions. VSFs are critical in cellular traction force production and migration. VSFs vary from randomly oriented short, thinner fibers to long, thick fibers that span along the

Homeobox B7 accelerates the cancer progression of gastric carcinoma cells by promoting epithelial-mesenchymal transition (EMT) and activating Src-FAK pathway.

Jianghong Wu et al.

OncoTargets and therapy, 12, 3743-3751 (2019-06-14)

Aim: To study the carcinogenetic mechanism of HOXB7 in gastric cancer (GC) remains. Methods: Two human GC cell lines - SGC7901 and SNU1 - were used for this study. SGC7901 cells were transfected with siRNA-HOXB7 (siHOXB7) to knock down HOXB7

Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion.

Patricia Costa et al.

PloS one, 8(9), e74659-e74659 (2013-09-17)

Cell invasion through extracellular matrix (ECM) is a hallmark of the metastatic cascade. Cancer cells require adhesion to surrounding tissues for efficient migration to occur, which is mediated through the integrin family of receptors. Alterations in expression levels of β1

Coupling to substrate adhesions drives the maturation of muscle stress fibers into myofibrils within cardiomyocytes.

Nilay Taneja et al.

Molecular biology of the cell, 31(12), 1273-1288 (2020-04-09)

Forces generated by heart muscle contraction must be balanced by adhesion to the extracellular matrix (ECM) and to other cells for proper heart function. Decades of data have suggested that cell-ECM adhesions are important for sarcomere assembly. However, the relationship

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Articles

Focal Adhesion Kinase (FAK) Overview

The focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase. FAK has been implicated as a downstream signaling molecule that functions in the control of several integrin-regulated biological processes.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Global Trade Item Number

SKU	GTIN
PZ0117-25MG	04061833220269
PZ0117-5MG	04061836687427

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