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Merck
CN

PZ0121

CP-135807

≥98% (HPLC)

Synonym(s):

3-(N-Methylpyrrolidin-2R-ylmethyl)-5-(3-nitropyrid-2- yl)amino-1H-indole, 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-N-(3-nitro-2-p yridinyl)-1H-indol-5-amine

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About This Item

Empirical Formula (Hill Notation):
C19H21N5O2
CAS Number:
151272-90-1
Molecular Weight:
351.40
NACRES:
NA.77
PubChem Substance ID:
329823712
UNSPSC Code:
51111800
MDL number:
MFCD00921453

Key Documents

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InChI

1S/C19H21N5O2/c1-23-9-3-4-15(23)10-13-12-21-17-7-6-14(11-16(13)17)22-19-18(24(25)26)5-2-8-20-19/h2,5-8,11-12,15,21H,3-4,9-10H2,1H3,(H,20,22)/t15-/m1/s1

SMILES string

CN1CCC[C@@H]1Cc2c[nH]c3ccc(Nc4ncccc4[N+]([O-])=O)cc23

InChI key

YPFIYPNOWVPAPR-OAHLLOKOSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +100 to +120°, c = 0.025 mg/mL in methanol

color

brown-red

solubility

DMSO: ≥5 mg/mL

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

CP-135807 is a selective 5-HT1D agonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
060M4713

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Charlotte Ahlgren et al.
European journal of pharmacology, 499(1-2), 67-75 (2004-09-15)
The in vitro pharmacological properties of AR-A000002 ((R)-N-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide), a novel 5-hydroxytryptamine (5-HT)(1B) receptor antagonist, were studied. AR-A000002 bound with high affinity to guinea pig cortex and recombinant guinea pig 5-HT(1B) receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity
H Rollema et al.
Journal of neurochemistry, 67(5), 2204-2207 (1996-11-01)
In vivo microdialysis in guinea pig hypothalamus was used to study the effect of serotonin [5-hydroxytryptamine (5-HT)] subtype 1D autoreceptor blockade on the increase in extracellular 5-HT levels produced by a selective 5-HT reuptake inhibitor (SSRI). Administration of the selective

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